Emergent responsive neurostimulation in pediatric super-refractory epilepsia partialis continua

IF 4.4 2区 医学 Q1 CLINICAL NEUROLOGY Annals of Clinical and Translational Neurology Pub Date : 2024-11-14 DOI:10.1002/acn3.52199
Peter N. Hadar, Pranav Nanda, Katherine G. Walsh, John McLaren, Alexandra Geffrey, Mirela Simon, Kristopher Kahle, R. Mark Richardson, Catherine J. Chu
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Abstract

Focal status epilepticus, particularly the motor variant of epilepsia partialis continua (EPC), is a rare condition characterized by near-continuous, chronic focal motor seizures, and associated with poor outcomes. Medications, including anesthetics, are often unsuccessful. Surgical resection can result in motor deficits. We report a medically complex pediatric case of super-refractory EPC that was successfully managed with combined focal resection and responsive neuromodulation. This case introduces neuromodulation as a treatment modality for this challenging condition.

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小儿超难治性癫痫部分性持续状态的紧急反应性神经刺激。
局灶性癫痫状态,尤其是癫痫部分性持续状态(EPC)的运动变异型,是一种罕见的疾病,其特点是近乎持续的慢性局灶性运动性癫痫发作,且预后不佳。包括麻醉剂在内的药物治疗往往无效。手术切除可能导致运动障碍。我们报告了一例病情复杂的超难治性癫痫发作儿科病例,该病例通过联合病灶切除术和反应性神经调控成功治愈。本病例介绍了神经调控作为治疗这种具有挑战性疾病的一种方法。
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来源期刊
Annals of Clinical and Translational Neurology
Annals of Clinical and Translational Neurology Medicine-Neurology (clinical)
CiteScore
9.10
自引率
1.90%
发文量
218
审稿时长
8 weeks
期刊介绍: Annals of Clinical and Translational Neurology is a peer-reviewed journal for rapid dissemination of high-quality research related to all areas of neurology. The journal publishes original research and scholarly reviews focused on the mechanisms and treatments of diseases of the nervous system; high-impact topics in neurologic education; and other topics of interest to the clinical neuroscience community.
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