Communication: 4-Hydroxynonenal and Fracture Risk in the Community-Dwelling Older People.

IF 1.1 4区医学 Q4 MEDICAL LABORATORY TECHNOLOGY Annals of clinical and laboratory science Pub Date : 2024-09-01

Nayuta Shimizu, Akihiro Saitsu, Kazuhiko Kotani

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引用次数: 0

Abstract

Objective: Oxidative stress is considered to increase fracture risk, and lipid oxidation can adversely affect bone health. 4-hydroxynonenal (4-HNE) is a representative marker of lipid oxidation.

Methods: We investigated the association between 4-HNE and fracture risk in community-dwelling older subjects (n=78, mean age=78 years). Serum albumin, C-reactive protein, and 4-HNE values were examined with the Fracture Risk Assessment Tool (FRAX®). The FRAX® score of >15% was defined as a high fracture risk.

Results: There was a significantly higher 4-HNE value in the group of high fracture risk (n=38, median=12.4 ng/mL) than in the low-risk group (n=40, median=9.8 ng/mL; p=0.02). The correlation of FRAX® major osteoporosis (β=0.45) and FRAX® hip fracture (β=0.44) with 4-HNE was significant after adjustment for multiple variables.

Conclusions: 4-HNE was suggested to be positively associated with fracture risk. This molecule may be a clinical candidate oxidative stress marker for fracture risk in the older population.

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交流：社区老年人的 4-羟基壬烯醛与骨折风险。

目的：氧化应激被认为会增加骨折风险，而脂质氧化会对骨骼健康产生不利影响。4-羟基壬烯醛（4-HNE）是脂质氧化的代表性标志物：我们调查了社区居住的老年人（人数=78，平均年龄=78 岁）中 4-HNE 与骨折风险之间的关系。我们使用骨折风险评估工具（FRAX®）对血清白蛋白、C 反应蛋白和 4-HNE 值进行了检测。FRAX®得分>15%被定义为高骨折风险：结果：骨折高风险组（38 人，中位数为 12.4 纳克/毫升）的 4-HNE 值明显高于低风险组（40 人，中位数为 9.8 纳克/毫升；P=0.02）。经多种变量调整后，FRAX®严重骨质疏松症（β=0.45）和FRAX®髋部骨折（β=0.44）与4-HNE的相关性显著：结论：4-HNE 与骨折风险呈正相关。结论：研究表明，4-HNE 与骨折风险呈正相关，该分子可能是老年人骨折风险的临床候选氧化应激标志物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of clinical and laboratory science 医学-医学实验技术

CiteScore

1.60

自引率

0.00%

发文量

112

审稿时长

6-12 weeks

期刊介绍： The Annals of Clinical & Laboratory Science welcomes manuscripts that report research in clinical science, including pathology, clinical chemistry, biotechnology, molecular biology, cytogenetics, microbiology, immunology, hematology, transfusion medicine, organ and tissue transplantation, therapeutics, toxicology, and clinical informatics.