Prevalence of Undernutrition and Its Contributing Factors Among Cancer Patients in Africa - A Systematic Review and Meta-Analysis of Observational Studies.

IF 3.2 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM Annals of Nutrition and Metabolism Pub Date : 2024-11-13 DOI:10.1159/000542390
Qasi Najah, Rasha Selim, Nereen A Almosilhy, Ahmed Asar, Moustafa Ibrahim, Ameerh Dana Sabe Alerab, Ebtesam Aldieb
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Abstract

Introduction: Cancer poses a significant burden in Africa, where limited resources and infrastructure compound the challenges of managing the disease. Undernutrition, a critical concern among cancer patients, can profoundly affect treatment outcomes and overall prognosis. Despite its importance, the prevalence of undernutrition among African cancer patients remains poorly understood.

Methods: Five major databases were searched for observational studies that reported the prevalence of undernutrition, from inception till February 2024. Study selection, data extraction, and quality assessment were conducted by at least two independent reviewers. The NIH criteria for observational studies were used for quality assessment. A random-effects meta-analysis model was used to estimate the overall undernutrition prevalence, with subgroup analyses conducted based on country and population characteristics.

Results: Twenty-four studies involving 4,283 participants met the inclusion criteria, most studies included children (41%), followed by adults (37%), and women (19%). The overall undernutrition prevalence among African cancer patients was estimated at 32.8% (95% CI, 25.1%, 41.67%) with substantial heterogeneity observed (I² = 95.4%, P < 0.0001). Subgroup analyses revealed significant variations in prevalence across countries and population groups.

Conclusion: Undernutrition is a serious issue among African cancer patients and requires an urgent response with targeted interventions. Tailored nutritional support strategies, considering demographic and regional contexts, are essential for improving patient outcomes.

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导言:癌症给非洲带来了沉重的负担,有限的资源和基础设施加剧了疾病管理的挑战。营养不良是癌症患者的一个重要问题,会严重影响治疗效果和整体预后。尽管营养不良很重要,但人们对非洲癌症患者营养不良的发生率仍然知之甚少:方法:在五个主要数据库中搜索了从开始到 2024 年 2 月报告营养不良发生率的观察性研究。研究选择、数据提取和质量评估由至少两名独立审稿人进行。质量评估采用美国国立卫生研究院的观察性研究标准。采用随机效应荟萃分析模型估算总体营养不良患病率,并根据国家和人口特征进行亚组分析:符合纳入标准的研究有 24 项,涉及 4283 名参与者,大多数研究包括儿童(41%),其次是成人(37%)和妇女(19%)。据估计,非洲癌症患者的总体营养不良发生率为 32.8%(95% CI,25.1%,41.67%),且存在很大的异质性(I² = 95.4%,P < 0.0001)。分组分析显示,不同国家和人群的患病率存在显著差异:营养不良是非洲癌症患者面临的一个严重问题,迫切需要采取有针对性的干预措施。考虑到人口和地区背景,量身定制的营养支持策略对于改善患者预后至关重要。
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来源期刊
Annals of Nutrition and Metabolism
Annals of Nutrition and Metabolism 医学-内分泌学与代谢
CiteScore
6.50
自引率
0.00%
发文量
55
审稿时长
6-12 weeks
期刊介绍: ''Annals of Nutrition and Metabolism'' is a leading international peer-reviewed journal for sharing information on human nutrition, metabolism and related fields, covering the broad and multidisciplinary nature of science in nutrition and metabolism. As the official journal of both the International Union of Nutritional Sciences (IUNS) and the Federation of European Nutrition Societies (FENS), the journal has a high visibility among both researchers and users of research outputs, including policy makers, across Europe and around the world.
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