Myeloid-Derived Suppressor Cells (MDSCs) and Obesity-Induced Inflammation in Type 2 Diabetes.

IF 3 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Diagnostics Pub Date : 2024-11-01 DOI:10.3390/diagnostics14212453
Larisa Ghemiș, Ancuța Goriuc, Bogdan Minea, Gina Eosefina Botnariu, Maria-Alexandra Mârțu, Melissa Ențuc, Daniel Cioloca, Liliana Georgeta Foia
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Abstract

Type 2 diabetes mellitus is a complex metabolic disorder characterized by insulin resistance and, subsequently, decreased insulin secretion. This condition is closely linked to obesity, a major risk factor that boosts the development of chronic systemic inflammation, which, in turn, is recognized for its crucial role in the onset of insulin resistance. Under conditions of obesity, adipose tissue, particularly visceral fat, becomes an active endocrine organ that releases a wide range of pro-inflammatory mediators, including cytokines, chemokines, and adipokines. These mediators, along with cluster of differentiation (CD) markers, contribute to the maintenance of systemic low-grade inflammation, promote cellular signaling and facilitate the infiltration of inflammatory cells into tissues. Emerging studies have indicated the accumulation of a new cell population in the adipose tissue in these conditions, known as myeloid-derived suppressor cells (MDSCs). These cells possess the ability to suppress the immune system, impacting obesity-related chronic inflammation. Given the limited literature addressing the role of MDSCs in the context of type 2 diabetes, this article aims to explore the complex interaction between inflammation, obesity, and MDSC activity. Identifying and understanding the role of these immature cells is essential not only for improving the management of type 2 diabetes but also for the potential development of targeted therapeutic strategies aimed at both glycemic control and the reduction in associated inflammation.

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髓系衍生抑制细胞(MDSCs)与肥胖诱发的 2 型糖尿病炎症。
2 型糖尿病是一种复杂的代谢紊乱疾病,其特点是胰岛素抵抗,随后胰岛素分泌减少。这种疾病与肥胖密切相关,肥胖是导致慢性全身性炎症的主要风险因素,而慢性全身性炎症又被认为在胰岛素抵抗的发生中起着至关重要的作用。在肥胖的情况下,脂肪组织,尤其是内脏脂肪,会成为一个活跃的内分泌器官,释放出多种促炎介质,包括细胞因子、趋化因子和脂肪因子。这些介质与分化群(CD)标记物一起,有助于维持全身性低度炎症,促进细胞信号传导,并促进炎症细胞向组织渗透。新近的研究表明,在这些情况下,脂肪组织中积累了一种新的细胞群,即髓源性抑制细胞(MDSCs)。这些细胞具有抑制免疫系统的能力,可影响与肥胖相关的慢性炎症。鉴于有关 MDSC 在 2 型糖尿病中作用的文献有限,本文旨在探讨炎症、肥胖和 MDSC 活性之间复杂的相互作用。识别和了解这些未成熟细胞的作用不仅对改善2型糖尿病的治疗至关重要,而且对开发旨在控制血糖和减少相关炎症的靶向治疗策略也至关重要。
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来源期刊
Diagnostics
Diagnostics Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry
CiteScore
4.70
自引率
8.30%
发文量
2699
审稿时长
19.64 days
期刊介绍: Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.
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