Neural correlates of expected and perceived treatment efficacy concerning open-label placebos for reducing emotional distress

IF 3.5 3区医学 Q2 NEUROSCIENCES Brain Research Bulletin Pub Date : 2024-11-06 DOI:10.1016/j.brainresbull.2024.111121

Anne Schienle , Albert Wabnegger

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Abstract

Background

Treatment expectations for open-label placebos (OLPs) - placebos prescribed transparently - refer to what a person anticipates will happen as a result of taking the placebo. The actual outcome of OLP treatment may deviate from the initial expectation.

Method

A total of 108 participants received OLP treatment for reducing visually induced emotional distress during functional magnetic resonance imaging. They rated the expected effect of the OLP before the experiment, and evaluated the perceived effect after the experiment. Ratings reflecting the degree of outcome deviation from expectation were correlated with brain activity in regions of interest (dorsolateral/ventrolateral prefrontal cortex, anterior cingulate cortex (ACC), insula, inferior parietal cortex).

Results

Activity in the ACC, the insula, and parietal regions (region-of-interest findings), as well as the parahippocampus (whole-brain finding) was lower when the perceived treatment outcome met or even exceeded expectations.

Conclusions

A positive expectation-outcome evaluation for the OLP was associated with reduced activity in brain regions decoding the salience (insula, ACC) and context of stimuli (parahippocampus). These findings shed light on the mechanisms through which OLPs influence emotion regulation.

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关于减少情绪困扰的开放标签安慰剂的预期疗效和感知疗效的神经相关性。

背景：对开放标签安慰剂（OLP）的治疗预期是指一个人预计服用安慰剂后会出现的结果。OLP治疗的实际结果可能会偏离最初的预期：方法：共有108名参与者接受了OLP治疗，以减轻功能性磁共振成像中视觉引起的情绪困扰。他们在实验前对 OLP 的预期效果进行评分，并在实验后对感知效果进行评估。反映结果偏离预期程度的评分与相关区域（背外侧/外侧前额叶皮层、前扣带回皮层（ACC）、脑岛、下顶叶皮层）的大脑活动相关：结果：当感知到的治疗结果达到甚至超过预期时，ACC、脑岛和顶叶区域（感兴趣区发现）以及海马旁（全脑发现）的活动较低：结论：对OLP的积极期望-结果评价与解读刺激显著性（脑岛、ACC）和上下文（海马旁）的脑区活动减少有关。这些发现揭示了OLP影响情绪调节的机制。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Brain Research Bulletin 医学-神经科学

CiteScore

6.90

自引率

2.60%

发文量

253

审稿时长

67 days

期刊介绍： The Brain Research Bulletin (BRB) aims to publish novel work that advances our knowledge of molecular and cellular mechanisms that underlie neural network properties associated with behavior, cognition and other brain functions during neurodevelopment and in the adult. Although clinical research is out of the Journal''s scope, the BRB also aims to publish translation research that provides insight into biological mechanisms and processes associated with neurodegeneration mechanisms, neurological diseases and neuropsychiatric disorders. The Journal is especially interested in research using novel methodologies, such as optogenetics, multielectrode array recordings and life imaging in wild-type and genetically-modified animal models, with the goal to advance our understanding of how neurons, glia and networks function in vivo.