Visual recovery following pituitary adenoma surgery: prognostic value of optical coherence tomography and suprasellar tumour volume.

Şerife Çiloğlu Hayat, Yusuf Cem Yılmaz, Buruç Erkan, Çağrı Erdim, İrem Önal, Serhat Ermiş, Esra Hatipoğlu
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Abstract

Objective: The aim of this study is to investigate the effects of preoperative parameters such as retinal nerve fiber layer (RNFL) thickness, visual acuity (VA), visual field (VF), and tumour volume on postoperative outcomes in patients with pituitary adenoma.

Design: Retrospective study.

Participants: Two-hundred and seventy-six eyes from 142 patients were included.

Methods: All patients underwent a comprehensive ophthalmological evaluation both before and 12 months after the surgery. RNFL thickness was analyzed using optical coherence tomography. VF testing was carried out using the automated Humphrey Visual Field Analyzer 3. Two primary visual field (VF) parameters, mean deviation (MD), and pattern standard deviation (PSD), were recorded. Patients were categorized into 2 groups based on their visual field outcomes: the MD recovery group and the nonrecovery group. MD recovery was defined as an MD value greater than -2 dB at the 12-month postoperative follow-up visit.

Results: The mean BCVA was significantly improved postoperatively compared with the preoperative values (P = 0.001). Preoperatively, the upper, temporal, and inferior RNFL values were significantly higher in patients with normal visual fields compared to those with abnormal visual fields (P = 0.001 for upper and temporal, P = 0.008 for inferior). Preoperative suprasellar tumour volume was found to be lower in the MD recovery group (P = 0.001). Multivariate logistic regression analyses revealed that preoperative inferior RNFL thickness were significantly associated with MD recovery (P = 0.023), and preoperative temporal RNFL thickness were significantly associated with VA recovery (P = 0.047).

Conclusion: RNFL thickness, VF parameters, and suprasellar tumour volume can serve as important prognostic indicators in patients with pituitary adenoma.

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垂体腺瘤手术后的视力恢复:光学相干断层扫描和鞍上肿瘤体积的预后价值。
研究目的本研究旨在探讨视网膜神经纤维层(RNFL)厚度、视力(VA)、视野(VF)和肿瘤体积等术前参数对垂体腺瘤患者术后预后的影响:设计:回顾性研究:方法:所有患者都接受了全面的眼科检查:所有患者在手术前和手术后 12 个月都接受了全面的眼科评估。使用光学相干断层扫描分析 RNFL 厚度。使用汉弗莱自动视野分析仪 3 进行视野测试。记录了两个主要视野(VF)参数,即平均偏差(MD)和模式标准偏差(PSD)。根据视野结果将患者分为两组:MD 恢复组和未恢复组。术后 12 个月随访时 MD 值大于-2 dB 即为 MD 恢复:结果:与术前相比,术后 BCVA 平均值明显改善(P = 0.001)。与视野异常的患者相比,术前视野正常的患者上部、颞部和下部 RNFL 值明显更高(上部和颞部 P = 0.001,下部 P = 0.008)。在 MD 恢复组中,术前鞍上肿瘤体积较小(P = 0.001)。多变量逻辑回归分析显示,术前下部RNFL厚度与MD恢复显著相关(P = 0.023),术前颞部RNFL厚度与VA恢复显著相关(P = 0.047):结论:RNFL厚度、VF参数和鞍上肿瘤体积可作为垂体腺瘤患者的重要预后指标。
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来源期刊
CiteScore
3.20
自引率
4.80%
发文量
223
审稿时长
38 days
期刊介绍: Official journal of the Canadian Ophthalmological Society. The Canadian Journal of Ophthalmology (CJO) is the official journal of the Canadian Ophthalmological Society and is committed to timely publication of original, peer-reviewed ophthalmology and vision science articles.
期刊最新文献
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