Efferocytosis: A new therapeutic target for stroke.

IF 7.5 3区医学 Q1 MEDICINE, GENERAL & INTERNAL Chinese Medical Journal Pub Date : 2024-11-12 DOI:10.1097/CM9.0000000000003363

Li Gao, Anatol Manaenko, Feng Zeng, Jingchen Li, Lele Liu, Ruichuan Xie, Xiaohua Zhang, John H Zhang, Qiyong Mei, Jiping Tang, Qin Hu

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Abstract

Abstract: Efferocytosis refers to the process that phagocytes recognize and remove the apoptotic cells, which is essential for maintaining tissue homeostasis both in physiological and pathological conditions. Numerous studies have demonstrated that efferocytosis can prevent secondary necrosis and proinflammatory factor release, leading to the resolution of inflammation and tissue immunological tolerance in numerous diseases such as stroke. Stroke is a leading cause of death and morbidity for adults worldwide. Persistent inflammation triggered by the dead cells or cell debris is a major contributor to post-stroke brain damage. Effective efferocytosis might be an efficient strategy to minimize inflammation and restore brain homeostasis for neuronal regeneration and function recovery. In this review, we will discuss the phagocytes in the brain, the molecular mechanisms underlying efferocytosis, the role of efferocytosis in inflammation resolution, and the potential therapeutic applications targeting efferocytosis in stroke.

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Efferocytosis：中风的新治疗靶点

摘要：吞噬作用是指吞噬细胞识别并清除凋亡细胞的过程，在生理和病理条件下对维持组织平衡至关重要。大量研究表明，吞噬细胞的排出可以防止继发性坏死和促炎因子的释放，从而在中风等多种疾病中消除炎症和组织免疫耐受。中风是全球成人死亡和发病的主要原因。死细胞或细胞碎片引发的持续炎症是中风后脑损伤的主要原因。有效的细胞外排可能是减少炎症、恢复脑平衡以促进神经元再生和功能恢复的有效策略。在这篇综述中，我们将讨论大脑中的吞噬细胞、流出细胞的分子机制、流出细胞在炎症消退中的作用以及针对中风流出细胞的潜在治疗应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chinese Medical Journal 医学-医学：内科

CiteScore

9.80

自引率

4.90%

发文量

19245

审稿时长

6 months

期刊介绍： The Chinese Medical Journal (CMJ) is published semimonthly in English by the Chinese Medical Association, and is a peer reviewed general medical journal for all doctors, researchers, and health workers regardless of their medical specialty or type of employment. Established in 1887, it is the oldest medical periodical in China and is distributed worldwide. The journal functions as a window into China’s medical sciences and reflects the advances and progress in China’s medical sciences and technology. It serves the objective of international academic exchange. The journal includes Original Articles, Editorial, Review Articles, Medical Progress, Brief Reports, Case Reports, Viewpoint, Clinical Exchange, Letter,and News,etc. CMJ is abstracted or indexed in many databases including Biological Abstracts, Chemical Abstracts, Index Medicus/Medline, Science Citation Index (SCI), Current Contents, Cancerlit, Health Plan & Administration, Embase, Social Scisearch, Aidsline, Toxline, Biocommercial Abstracts, Arts and Humanities Search, Nuclear Science Abstracts, Water Resources Abstracts, Cab Abstracts, Occupation Safety & Health, etc. In 2007, the impact factor of the journal by SCI is 0.636, and the total citation is 2315.