Polymorphism rs564398 of the ANRIL Gene as a Coronary-Artery-Disease-Associated SNP in Diabetic Patients of the Kazakh Population.

IF 3 3区医学 Q1 MEDICINE, GENERAL & INTERNAL Diagnostics Pub Date : 2024-10-29 DOI:10.3390/diagnostics14212412

Alisher Aitkaliyev, Nazira Bekenova, Tamara Vochshenkova, Balzhan Kassiyeva, Valeriy Benberin

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Abstract

Background/objectives: A cardiovascular complication of type 2 diabetes mellitus like coronary artery disease is influenced by a complex interplay between environmental, phenotypic, and genetic factors. The genetic mechanisms in the development of this pathology are not established. This study aims to evaluate the association of polymorphisms rs1011970, rs62560775, and rs564398 from the 9p21.3 locus with coronary artery disease in diabetic patients of the Kazakh population.

Methods: A total of 343 people participated in the case-control study: the control group consisted of 109 people with type 2 diabetes and coronary artery disease, while the control group included 234 people. Genotyping was performed using real-time PCR. Statistical analysis was carried out using Chi-square methods and calculating odds ratios (OR) with 95% confidence intervals (CI).

Results: According to the results, only the rs564398 polymorphism of the ANRIL gene was associated with coronary artery disease (p = 0.04). The CC genotype increased the risk of developing coronary artery disease by more than 1.5 times (1.62 (1.02-2.56)), whereas the TT genotype reduced the risk of coronary artery disease (0.39 (0.17-0.91)). The remaining polymorphisms, rs1011970 and rs62560775, were not associated with coronary artery disease.

Conclusions: Thus, this research further elicits the association of the ANRIL gene with cardiometabolic disease.

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哈萨克族糖尿病患者中与冠状动脉疾病相关的 ANRIL 基因多态性 rs564398。

背景/目的：2 型糖尿病的心血管并发症（如冠状动脉疾病）受环境、表型和遗传因素之间复杂相互作用的影响。该病症发生的遗传机制尚未确定。本研究旨在评估 9p21.3 位点的多态性 rs1011970、rs62560775 和 rs564398 与哈萨克族糖尿病患者冠状动脉疾病的关系：共有 343 人参加了病例对照研究：对照组包括 109 名 2 型糖尿病和冠状动脉疾病患者，对照组包括 234 人。基因分型采用实时 PCR 技术进行。统计分析采用Chi-square方法，计算几率比（OR）和95%置信区间（CI）：结果显示，只有 ANRIL 基因的 rs564398 多态性与冠心病相关（p = 0.04）。CC 基因型会使冠心病发病风险增加 1.5 倍以上（1.62 (1.02-2.56)），而 TT 基因型则会降低冠心病发病风险（0.39 (0.17-0.91)）。其余的多态性 rs1011970 和 rs62560775 与冠心病无关：因此，这项研究进一步揭示了 ANRIL 基因与心脏代谢疾病的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diagnostics Biochemistry, Genetics and Molecular Biology-Clinical Biochemistry

CiteScore

4.70

自引率

8.30%

发文量

2699

审稿时长

19.64 days

期刊介绍： Diagnostics (ISSN 2075-4418) is an international scholarly open access journal on medical diagnostics. It publishes original research articles, reviews, communications and short notes on the research and development of medical diagnostics. There is no restriction on the length of the papers. Our aim is to encourage scientists to publish their experimental and theoretical research in as much detail as possible. Full experimental and/or methodological details must be provided for research articles.