Risk Factors Associated with Amputation for Patients with Diabetic Foot Ulcers: A Retrospective Study.

IF 2.8 3区医学 Q3 ENDOCRINOLOGY & METABOLISM Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2024-11-07 eCollection Date: 2024-01-01 DOI:10.2147/DMSO.S490614

Bo Yang, Xuwen Zha, Yunling Ding

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Abstract

Objective: Diabetic foot ulcer (DFU) and related amputation significantly contribute to morbidity rates. The objective of this study was to assess the risk factors correlated with amputation in Chinese patients with DFU.

Methods: A prospective study was implemented on DFU patients at Third Affiliated Hospital of Anhui Medical University from February 2016 to May 2024. Patients were categorized into two groups based on whether they underwent amputation: the amputation group (n = 33) and the non-amputation group (n = 29). A comparative analysis was conducted between two groups, focusing on demographic data, disease characteristics, and laboratory indicators. Binary and multivariate logistic regressions were employed to evaluate the risk factors associated with amputation. Receiver Operating Characteristic curve analysis was used to assess the risk factors in predicting amputation in patients with DFU.

Results: The incidence of history of amputation, duration of diabetes in the amputation group were significantly increased compared to the non-amputation group (P < 0.05). On the contrary, the red blood cell count, hemoglobin level, and hematocrit in the amputation group were significantly lower compared to the non-amputation group (P < 0.05). Moreover, in the bi-variable logistic regression analysis, the duration of diabetes, duration of DFU, history of amputation, and hemoglobin levels were significantly associated with amputation (P < 0.05). After controlling potential confounding factors in multiple logistic regression analysis, duration of DFU was identified as a determining factor for amputation (P < 0.05). Additionally, the values for the area under curve (AUC) in relation to the duration of diabetes, duration of DFU, history of amputation, and a combined panel in predicting the occurrence of amputation in patients with DFU were 0.890, 0.868, 0.730, and 0.916, respectively.

Conclusion: Our findings indicate that duration of DFU is an independent risk factor for amputation in patients with DFU.

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糖尿病足溃疡患者截肢的相关风险因素：一项回顾性研究

目的：糖尿病足溃疡（DFU）及相关截肢是发病率的重要组成部分。本研究旨在评估与中国 DFU 患者截肢相关的风险因素：方法：2016 年 2 月至 2024 年 5 月，安徽医科大学第三附属医院对 DFU 患者实施了一项前瞻性研究。根据是否截肢将患者分为两组：截肢组（33 人）和非截肢组（29 人）。对两组患者的人口统计学数据、疾病特征和实验室指标进行了比较分析。采用二元和多元逻辑回归评估与截肢相关的风险因素。采用接收者操作特征曲线分析法评估了预测DFU患者截肢的风险因素：结果：与未截肢组相比，截肢组中截肢史和糖尿病病程的发生率明显增加（P < 0.05）。相反，截肢组的红细胞计数、血红蛋白水平和血细胞比容明显低于未截肢组（P < 0.05）。此外，在双变量逻辑回归分析中，糖尿病病程、DFU 病程、截肢史和血红蛋白水平与截肢显著相关（P < 0.05）。在多重逻辑回归分析中控制了潜在的混杂因素后，DFU持续时间被确定为截肢的决定性因素（P < 0.05）。此外，与糖尿病病程、DFU 病程、截肢史以及预测 DFU 患者截肢发生的综合面板相关的曲线下面积（AUC）值分别为 0.890、0.868、0.730 和 0.916：我们的研究结果表明，DFU持续时间是DFU患者截肢的独立风险因素。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.