Warmblood fragile foal syndrome: Pregnancy loss in Warmblood mares.

IF 2.4 2区 农林科学 Q1 VETERINARY SCIENCES Equine Veterinary Journal Pub Date : 2024-11-14 DOI:10.1111/evj.14435
A Kehlbeck, M Blanco, Monica Venner, Fritjof Freise, B Gunreben, Harald Sieme
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Abstract

Background: Fragile foal syndrome (FFS) or warmblood FFS Type 1 (WFFS) is a recessive, autosomal, hereditary, genetic defect causing late abortions, stillbirths and non-viable foals. Whether early pregnancy losses occur is unknown.

Objectives: To investigate how WFFS affects pregnancies and whether early pregnancy losses occur in WFFS matings and if there is a difference in pregnancy success between matings where both parents were allele carriers and those where only mare or stallion were WFFS carriers.

Study design: Retrospective cohort study.

Methods: Breeding records from a Warmblood stud farm were evaluated (2016-2019) and 2682 cycles of 177 mares analysed. Matings were assigned to four study groups, depending on the WFFS carrier status of the mare and stallion: N/WFFS × N/WFFS (n = 46), N/WFFS (mares) × N/N (n = 511), N/N × N/WFFS (stallions) (n = 191) and N/N × N/N (n = 2149).

Results: There were no differences in pregnancy rates between matings with only one WFFS carrier and those with non-carriers. When comparing N/WFFS × N/WFFS matings to those with only one or no WFFS-carrier, there were no increased pregnancy losses in the embryonic phase (day <42). By contrast, the N/WFFS × N/WFFS group had significantly more abortions (53.8%) than the other three study groups (7.9-9.2%; adjusted p < 0.0001). The higher losses were evenly distributed between the early (D42-150: 22.7% losses, n = 5) and late (D150-300: 29.4% losses, n = 5) foetal phase. The live foal rate per pregnancy for N/WFFS × N/WFFS matings was lowest (34.5%) and differed significantly (other groups 81%-84%; adjusted p < 0.0001); the peri- and postnatal mortality was higher (25%) compared with the other study groups (2.6%-3%).

Main limitations: Low sample size in N/WWFS × N/WFFS matings, unbalanced study design, outcomes are descriptive, all mares from one stud farm.

Conclusions: The mating of two WFFS carriers may lead to increased risks of pregnancy and foal loss.

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温血马脆胎综合症:温血母马的妊娠损失。
背景:脆性马驹综合征(FFS)或温血动物脆性马驹综合征 1 型(WFFS)是一种隐性、常染色体遗传性遗传缺陷,可导致晚期流产、死胎和无法存活的马驹。是否会发生早期妊娠损失尚不清楚:研究设计:回顾性队列研究:研究设计:回顾性队列研究:对一个温血马种马场的繁殖记录进行评估(2016-2019 年),分析了 177 头母马的 2682 个配种周期。根据母马和公马的 WFFS 携带者状态,将配种分配到四个研究组:N/WFFS×N/WFFS(n=46)、N/WFFS(母马)×N/N(n=511)、N/N×N/WFFS(种公马)(n=191)和N/N×N/N(n=2149):结果:只有一个 WFFS 携带者的配种与非携带者的配种在受孕率上没有差异。将 N/WFFS × N/WFFS 配对与只有一个或没有 WFFS 携带者的配对进行比较,胚胎期(主要限制日)的妊娠损失没有增加:N/WWFS × N/WFFS 交配的样本量较少,研究设计不平衡,结果是描述性的,所有母马来自一个种马场:结论:两个 WFFS 携带者交配可能会导致妊娠和马驹损失的风险增加。
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来源期刊
Equine Veterinary Journal
Equine Veterinary Journal 农林科学-兽医学
CiteScore
5.10
自引率
13.60%
发文量
161
审稿时长
6-16 weeks
期刊介绍: Equine Veterinary Journal publishes evidence to improve clinical practice or expand scientific knowledge underpinning equine veterinary medicine. This unrivalled international scientific journal is published 6 times per year, containing peer-reviewed articles with original and potentially important findings. Contributions are received from sources worldwide.
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