Cardiovascular Health Metrics of Spouses of Indian Women with a History of Gestational Diabetes and Diabetes in Pregnancy: Results from CHIP-F Study.

IF 3.8 3区医学 Q2 Medicine Diabetes Therapy Pub Date : 2024-11-09 DOI:10.1007/s13300-024-01662-y

Yashdeep Gupta, Alpesh Goyal, Samita Ambekar, Mani Kalaivani, Neerja Bhatla, Nikhil Tandon

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Abstract

Introduction: There are limited data on the prevalence of cardiovascular risk factors/diseases (diabetes, obesity, hypertension, and dyslipidemia) and their composite scores reflecting overall cardiovascular health among young (< 50 years old) married couples.

Methods: We have an established longitudinal prospective cohort of postpartum women with a history of hyperglycemia [pre-existing diabetes (PED; n = 101), overt diabetes in pregnancy (ODiP; n = 92), gestational diabetes (GDM; n = 643)], and normoglycemia (n = 183) in pregnancy and their spouses (n = 819). In this study, we report data from baseline cross-sectional evaluation of these 819 young couples regarding the burden of cardiovascular risk factors/diseases, their concordance and associations.

Results: The mean (SD) age was 33.5 (4.9) years for women and 36.9 (5.4) years for men, and the evaluation was performed at a median (IQR) postpartum interval of 30 (20-45) months. Diabetes, hypertension, obesity, and dyslipidemia were present in 25.0%, 6.9%, 25.6%, and 4.0% of women and 15.8%, 20.2%, 14.3%, and 8.2% of men, respectively. Among men, dysglycemia (diabetes/prediabetes) and adverse cardiovascular score (average/poor) showed a significant trend in progression according to the antenatal categories of their partner (highest in DIP, intermediate in GDM, and lowest in normoglycemia). The concordance was higher for adverse cardiovascular score (58.5%), overweight/obesity (48.7%), and dysglycemia (42.4%) compared to prehypertension/hypertension (29.2%) and hypercholesterolemia (8.2%). The odds ratios were significant for all associations evaluated, except for elevated blood pressure, being strongest (OR > 2.0) for overweight/obesity and adverse cardiovascular score.

Conclusions: Nearly three in five young couples evaluated in the study showed concordance for adverse cardiovascular scores. The cardiovascular risk in men increased in a graded manner across the increasing severity of antenatal glycemic categories of their partners.

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有妊娠糖尿病史和孕期糖尿病史的印度妇女配偶的心血管健康指标：CHIP-F研究的结果

导言：关于心血管危险因素/疾病（糖尿病、肥胖、高血压和血脂异常）的患病率及其反映年轻人整体心血管健康状况的综合评分的数据有限（方法：我们建立了一个纵向前瞻性队列，对有高血糖病史的产后妇女[已有糖尿病（PED；n = 101）]进行研究：我们建立了一个纵向前瞻性队列，对象是有高血糖病史的产后妇女[妊娠前糖尿病（PED；n = 101）、妊娠期明显糖尿病（ODiP；n = 92）、妊娠期糖尿病（GDM；n = 643）]和妊娠期血糖正常妇女（n = 183）及其配偶（n = 819）。在本研究中，我们报告了对这 819 对年轻夫妇进行的基线横断面评估数据，内容涉及心血管风险因素/疾病的负担、它们之间的一致性和关联性：女性的平均（标清）年龄为 33.5（4.9）岁，男性的平均（标清）年龄为 36.9（5.4）岁，评估是在产后 30（20-45）个月的中位数（IQR）间隔时间内进行的。分别有 25.0%、6.9%、25.6% 和 4.0% 的女性和 15.8%、20.2%、14.3% 和 8.2% 的男性患有糖尿病、高血压、肥胖症和血脂异常。在男性中，血糖异常（糖尿病/胰岛素抵抗）和心血管不良评分（一般/较差）随其伴侣的产前类别（DIP最高，GDM居中，血糖正常最低）而呈显著上升趋势。与高血压前期/高血压（29.2%）和高胆固醇血症（8.2%）相比，心血管不良评分（58.5%）、超重/肥胖（48.7%）和血糖异常（42.4%）的一致性更高。除血压升高外，所有评估的相关因素的几率比都很大，其中超重/肥胖和心血管不良评分的几率比最大（OR > 2.0）：结论：在这项研究中，近五分之三的年轻夫妇在心血管不良评分方面表现一致。男性的心血管风险随着其伴侣产前血糖类别严重程度的增加而分级增加。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes Therapy Medicine-Endocrinology, Diabetes and Metabolism

CiteScore

6.90

自引率

7.90%

发文量

130

审稿时长

6 weeks

期刊介绍： Diabetes Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all areas of diabetes. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Diabetes Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.