Red cell distribution width: a potential marker of reduced femoral neck bone mineral density in men and postmenopausal women.

IF 3.7 3区医学 Q2 Medicine Endocrine Pub Date : 2024-11-14 DOI:10.1007/s12020-024-04093-8

Zhengrong Qi, Liang Zhang, Zhiyao Li, Haomiao Yu, Qiang Li, Lifeng Ma, Yan Yang

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Abstract

Purpose: Osteoporosis imposes significant burdens. Early detection of high-risk individuals through simple indicators can greatly improve prognosis. Red cell distribution width (RDW), a standard component of a complete blood count, shows promise, yet remains underexplored. This cross-sectional study aimed to investigate the association between RDW and femoral neck and spinal bone mineral density (BMD).

Methods: Participants aged 20-79 years from the 2005-2010, 2013-2014, and 2017-2020 cycles of the National Health and Nutrition Examination Survey (NHANES) were included. BMD was measured using dual-energy X-ray absorptiometry (DXA).

Results: A total of 13,029 participants were included, comprising 6684 men, 3238 postmenopausal women, and 3107 premenopausal women, with the sample weighted to represent 98,712,128 people. After adjusting for covariates, RDW exhibited a negative association with femoral neck BMD in both men (β = -0.006; 95% CI: -0.010 to -0.002; p = 0.0053) and postmenopausal women (β = -0.005; 95% CI: -0.010 to -0.000; p = 0.0413). Subgroup and sensitivity analyses supported the robustness of these findings. A negative association between RDW and spinal BMD in men approached significance (β = -0.004; 95% CI: -0.008 to 0.000; p = 0.0557). Persistent trends were observed for RDW with spinal BMD in postmenopausal women and with both femoral neck and spinal BMD in premenopausal women.

Conclusions: Our study suggests a negative association between RDW and femoral neck BMD in both men and postmenopausal women. These findings highlight the potential of RDW as a marker for identifying individuals at higher risk of osteoporosis.

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红细胞分布宽度：男性和绝经后女性股骨颈骨质密度降低的潜在标志。

目的：骨质疏松症给人们带来了沉重的负担。通过简单的指标及早发现高危人群可大大改善预后。红细胞分布宽度（RDW）是全血细胞计数的一个标准组成部分，它显示出了良好的前景，但仍未得到充分探索。这项横断面研究旨在调查红细胞分布宽度与股骨颈和脊柱骨矿物质密度（BMD）之间的关系：方法：纳入 2005-2010、2013-2014 和 2017-2020 年国家健康与营养调查（NHANES）周期中 20-79 岁的参与者。采用双能 X 射线吸收测定法（DXA）测量 BMD：共纳入 13,029 名参与者，包括 6684 名男性、3238 名绝经后女性和 3107 名绝经前女性，样本加权后代表 98,712,128 人。调整协变量后，RDW 与男性（β = -0.006; 95% CI: -0.010 to -0.002; p = 0.0053）和绝经后女性（β = -0.005; 95% CI: -0.010 to -0.000; p = 0.0413）的股骨颈 BMD 呈负相关。分组分析和敏感性分析证实了这些发现的可靠性。男性 RDW 与脊柱 BMD 之间的负相关接近显著性（β = -0.004; 95% CI: -0.008 to 0.000; p = 0.0557）。在绝经后妇女中，观察到 RDW 与脊柱 BMD 呈持续趋势，在绝经前妇女中，观察到 RDW 与股骨颈和脊柱 BMD 呈持续趋势：我们的研究表明，男性和绝经后女性的 RDW 与股骨颈 BMD 之间存在负相关。这些发现凸显了 RDW 作为识别骨质疏松症高危人群的标志物的潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine 医学-内分泌学与代谢

CiteScore

6.40

自引率

5.40%

发文量

期刊介绍： Well-established as a major journal in today’s rapidly advancing experimental and clinical research areas, Endocrine publishes original articles devoted to basic (including molecular, cellular and physiological studies), translational and clinical research in all the different fields of endocrinology and metabolism. Articles will be accepted based on peer-reviews, priority, and editorial decision. Invited reviews, mini-reviews and viewpoints on relevant pathophysiological and clinical topics, as well as Editorials on articles appearing in the Journal, are published. Unsolicited Editorials will be evaluated by the editorial team. Outcomes of scientific meetings, as well as guidelines and position statements, may be submitted. The Journal also considers special feature articles in the field of endocrine genetics and epigenetics, as well as articles devoted to novel methods and techniques in endocrinology. Endocrine covers controversial, clinical endocrine issues. Meta-analyses on endocrine and metabolic topics are also accepted. Descriptions of single clinical cases and/or small patients studies are not published unless of exceptional interest. However, reports of novel imaging studies and endocrine side effects in single patients may be considered. Research letters and letters to the editor related or unrelated to recently published articles can be submitted. Endocrine covers leading topics in endocrinology such as neuroendocrinology, pituitary and hypothalamic peptides, thyroid physiological and clinical aspects, bone and mineral metabolism and osteoporosis, obesity, lipid and energy metabolism and food intake control, insulin, Type 1 and Type 2 diabetes, hormones of male and female reproduction, adrenal diseases pediatric and geriatric endocrinology, endocrine hypertension and endocrine oncology.