Association Between Serum Uric Acid and Pregnancy Outcomes: A Study in Chinese Women.

IF 1.5 4区医学 Q4 ENDOCRINOLOGY & METABOLISM Endocrine Research Pub Date : 2024-11-14 DOI:10.1080/07435800.2024.2427612

Yibo Zhou, Xia Gao, Yu An, Jia Liu, Guang Wang

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Abstract

Objective: The study aims to explore the relationship between serum uric acid (UA) levels in the first trimester and pregnancy outcomes.

Methods: The clinical data of 1381 pregnant women who delivered in the Department of Obstetrics and Gynecology of Beijing Chao-Yang Hospital from June 2021 to July 2022 were collected. All patients were categorized into four groups (Q1-Q4) according to quartiles of UA, using the first quartile of UA as the reference group. Logistic regression analysis was used to observe the correlation between UA and pregnancy outcomes. Restricted cubic spline (RCS) was drawn to observe the dose-response relationship between UA and pregnancy outcomes.

Results: The numbers of GDM patients in Q1-Q4 were 40 (11.70%), 46 (13.49%), 60 (17.29%) and 83 (23.65%), respectively (p < 0.001). Logistic regression analysis showed that higher quartiles of UA were significantly associated with an increased prevalence of gestational diabetes mellitus (GDM). After adjusting for confounding factors (maternal age, prepregnancy BMI, gestational weight gain, and gestational age), compared with the lowest quartile of UA, the highest quartile of UA had 2.06 times odds of GDM (OR, 2.06; 95% CI, 1.34, 3.18; p = 0.001) in Q4. RCS suggested that the risk of GDM increased slowly until UA levels reached 219.43 µmol/L and then began to increase rapidly afterward (overall p = 0.0037).

Conclusions: Increased uric acid concentrations in the first trimester are associated with an increased risk of GDM and gestational hypertension.

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血清尿酸与妊娠结局的关系：中国妇女研究

研究目的本研究旨在探讨妊娠头三个月血清尿酸（UA）水平与妊娠结局之间的关系：收集 2021 年 6 月至 2022 年 7 月期间在北京朝阳医院妇产科分娩的 1381 名孕妇的临床资料。以 UA 的第一四分位数为参照组，根据 UA 的四分位数将所有患者分为四组（Q1-Q4）。采用逻辑回归分析观察 UA 与妊娠结局之间的相关性。绘制限制立方样条线（RCS）以观察 UA 与妊娠结局之间的剂量-反应关系：第一季度至第四季度的 GDM 患者人数分别为 40 人（11.70%）、46 人（13.49%）、60 人（17.29%）和 83 人（23.65%）（P = 0.001）。RCS 表明，在尿酸水平达到 219.43 µmol/L 之前，患 GDM 的风险缓慢上升，之后开始快速上升（总 p = 0.0037）：结论：妊娠头三个月尿酸浓度升高与 GDM 和妊娠高血压风险增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Endocrine Research 医学-内分泌学与代谢

CiteScore

4.30

自引率

0.00%

发文量

审稿时长

>12 weeks

期刊介绍： This journal publishes original articles relating to endocrinology in the broadest context. Subjects of interest include: receptors and mechanism of action of hormones, methodological advances in the detection and measurement of hormones; structure and chemical properties of hormones. Invitations to submit Brief Reviews are issued to specific authors by the Editors.

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