Reproductive, obstetrical and oncological outcomes of fertility-sparing treatment for cervical cancer according to the FIGO 2018 staging system: A systematic review

IF 3.5 2区医学 Q2 ONCOLOGY Ejso Pub Date : 2024-11-07 DOI:10.1016/j.ejso.2024.109359

Cristina Taliento , Gennaro Scutiero , Ginevra Battello , Alessia Sala , Giulia Pellecchia , Rita Trozzi , Martina Arcieri , Matteo Pavone , Nicolò Bizzarri , Pantaleo Greco , Lorenza Driul , Frédéric Amant , Anna Fagotti , Giovanni Scambia , Giuseppe Vizzielli , Stefano Restaino

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Abstract

Objective

We assessed reproductive, obstetrical, and oncological outcomes in patients who underwent fertility-sparing treatment by including studies that adhere to the FIGO 2018 staging system.

Methods

Data on recurrence, mortality, pregnancy rate, live birth rate, and preterm delivery rate were collected.

Results

In patients with stages IA1, IA2, and IB1, the recurrence rate was 4.7 % and the death rate was 0.6 %. For patients with stage IB2, the recurrence rate was 12.1 % and the death rate was 3.2 %. Pregnancy rates for conization/simple trachelectomy and radical trachelectomy were 61.7 % and 50 %, respectively. A higher live birth rate (84.4 % vs 58.6 %), and lower preterm birth rate (18.3 % vs 33.3 %) were observed in patients undergoing conization compared to radical trachelectomy.

Conclusion

We found a recurrence rate of 4.7 % in patients with stage less than or equal to IB1 and 12.1 % in those with stage IB2. A higher rate of preterm delivery was observed in patients who underwent radical trachelectomy.

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根据 FIGO 2018 分期系统对宫颈癌进行保胎治疗的生殖、产科和肿瘤学结果：系统综述。

目的我们通过纳入遵循 FIGO 2018 分期系统的研究，评估了接受保胎治疗患者的生殖、产科和肿瘤结局：收集了复发率、死亡率、妊娠率、活产率和早产率等数据：IA1、IA2和IB1期患者的复发率为4.7%，死亡率为0.6%。IB2 期患者的复发率为 12.1%，死亡率为 3.2%。锥切/简单气管切除术和根治性气管切除术的妊娠率分别为61.7%和50%。与根治性气管切除术相比，锥切术患者的活产率更高（84.4% 对 58.6%），早产率更低（18.3% 对 33.3%）：我们发现，IB1 期以下患者的复发率为 4.7%，IB2 期患者的复发率为 12.1%。接受根治性气管切除术的患者早产率较高。

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来源期刊

Ejso 医学-外科

CiteScore

6.40

自引率

2.60%

发文量

1148

审稿时长

41 days

期刊介绍： JSO - European Journal of Surgical Oncology ("the Journal of Cancer Surgery") is the Official Journal of the European Society of Surgical Oncology and BASO ~ the Association for Cancer Surgery. The EJSO aims to advance surgical oncology research and practice through the publication of original research articles, review articles, editorials, debates and correspondence.