The clinical prospects and challenges of photothermal nanomaterials in myocardium recovery after myocardial infarction.

IF 4.3 3区工程技术 Q1 BIOTECHNOLOGY & APPLIED MICROBIOLOGY Frontiers in Bioengineering and Biotechnology Pub Date : 2024-10-29 eCollection Date: 2024-01-01 DOI:10.3389/fbioe.2024.1491581

Jiali Yang, Jian He, Tian Yue, Haifeng Pei, Shiqiang Xiong, Yue Tang, Jun Hou

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Abstract

The high morbidity and mortality rates associated with myocardial infarction pose a serious threat to human health. Early diagnosis and appropriate treatment are crucial in saving the lives of patients. In recent years, nanomaterials-based technologies have played a significant role in developing new strategies for cardiac repair, particularly in the use of photothermal nanomaterials, which show great potential in treating myocardial infarction. This review aims to describe the characteristics of photothermal nanomaterials, their effects on cardiomyocyte proliferation and angiogenesis, and the mechanism of cardiac tissue repair. This review serves as a valuable reference for the application of photothermal nanomaterials in the treatment of myocardial infarction, with the ultimate goal of expediting the translation of these treatment strategies into clinical practice.

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光热纳米材料在心肌梗死后心肌恢复中的临床前景和挑战。

与心肌梗死相关的高发病率和高死亡率对人类健康构成严重威胁。早期诊断和适当治疗是挽救患者生命的关键。近年来，基于纳米材料的技术在开发心脏修复新策略方面发挥了重要作用，尤其是光热纳米材料的使用，在治疗心肌梗死方面显示出巨大潜力。本综述旨在描述光热纳米材料的特性、对心肌细胞增殖和血管生成的影响以及心脏组织修复的机制。本综述为光热纳米材料在心肌梗死治疗中的应用提供了有价值的参考，其最终目的是加快将这些治疗策略转化为临床实践。

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来源期刊

Frontiers in Bioengineering and Biotechnology Chemical Engineering-Bioengineering

CiteScore

8.30

自引率

5.30%

发文量

2270

审稿时长

12 weeks

期刊介绍： The translation of new discoveries in medicine to clinical routine has never been easy. During the second half of the last century, thanks to the progress in chemistry, biochemistry and pharmacology, we have seen the development and the application of a large number of drugs and devices aimed at the treatment of symptoms, blocking unwanted pathways and, in the case of infectious diseases, fighting the micro-organisms responsible. However, we are facing, today, a dramatic change in the therapeutic approach to pathologies and diseases. Indeed, the challenge of the present and the next decade is to fully restore the physiological status of the diseased organism and to completely regenerate tissue and organs when they are so seriously affected that treatments cannot be limited to the repression of symptoms or to the repair of damage. This is being made possible thanks to the major developments made in basic cell and molecular biology, including stem cell science, growth factor delivery, gene isolation and transfection, the advances in bioengineering and nanotechnology, including development of new biomaterials, biofabrication technologies and use of bioreactors, and the big improvements in diagnostic tools and imaging of cells, tissues and organs. In today`s world, an enhancement of communication between multidisciplinary experts, together with the promotion of joint projects and close collaborations among scientists, engineers, industry people, regulatory agencies and physicians are absolute requirements for the success of any attempt to develop and clinically apply a new biological therapy or an innovative device involving the collective use of biomaterials, cells and/or bioactive molecules. “Frontiers in Bioengineering and Biotechnology” aspires to be a forum for all people involved in the process by bridging the gap too often existing between a discovery in the basic sciences and its clinical application.