Social Determinants of 6-Mercaptopurine Adherence Among Patients with Acute Lymphoblastic Leukemia/Lymphoma: A Cross-Sectional Analysis.

IF 1.2 4区 医学 Q4 ONCOLOGY Journal of adolescent and young adult oncology Pub Date : 2024-11-11 DOI:10.1089/jayao.2024.0119
Ayah El-Khatib, Kevin Matos, Jenna Rossoff, Alexandra Psihogios
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Abstract

Acute lymphoblastic leukemia requires around 18 months of daily oral chemotherapy called 6-mercaptopurine (6-MP) for treatment. Previous research has included a broad age range and shows adolescent/young adult (AYA) age and minoritized race/ethnicity are associated with lower adherence. Few studies have evaluated how these intersecting identities impact adherence. In a retrospective analysis of an AYA sample, we evaluated the relationships between race/ethnicity, area deprivation index (ADI), and insurance with electronically monitored 6-MP adherence. Results showed minoritized race/ethnicity and ADI correlated with adherence. Findings highlight the need for equitable interventions that enhance adherence and improve outcomes among AYAs.

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急性淋巴细胞白血病/淋巴瘤患者坚持服用 6-巯基嘌呤的社会决定因素:横断面分析
急性淋巴细胞白血病需要接受约 18 个月的每日口服化疗,即 6-巯基嘌呤(6-MP)治疗。以往的研究涵盖了广泛的年龄范围,并显示青少年/年轻成人(AYA)年龄和少数种族/民族与较低的依从性有关。但很少有研究评估了这些交叉身份对坚持治疗的影响。在一项针对青少年样本的回顾性分析中,我们评估了种族/民族、地区贫困指数(ADI)和保险与电子监控 6-MP 依从性之间的关系。结果显示,少数种族/民族和地区贫困指数与坚持治疗有关。研究结果突出表明,有必要采取公平的干预措施,以提高青壮年患者的依从性并改善其治疗效果。
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来源期刊
CiteScore
3.70
自引率
15.00%
发文量
114
期刊介绍: Journal of Adolescent and Young Adult Oncology (JAYAO) breaks new ground as the first cancer journal dedicated to all aspects of adolescent and young adult (AYA)-aged cancer patients and survivors. JAYAO is the only central forum for peer-reviewed articles, reviews, and research in the field, bringing together all AYA oncology stakeholders and professionals across disciplines, including clinicians, researchers, psychosocial and supportive care providers, and pediatric and adult cancer institutions.
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