New idea of Fuke Qianjin capsule in treating sequelae of pelvic inflammatory disease: Anti-inflammatory in the early stage and reparative in the later stage.

IF 4.8 2区医学 Q1 CHEMISTRY, MEDICINAL Journal of ethnopharmacology Pub Date : 2024-11-09 DOI:10.1016/j.jep.2024.119066

Chunfang Xu, Meijin Yi, Zhikui Xiao, Feng Xiang, Mengyao Wu, Zhimin Zhang, Yuanqing Zheng, Yun Gong, Yamei Li, Liang Su, Yingyan Liao, Peng Zhang, Bohou Xia, Duanfang Liao, Limei Lin

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Abstract

Ethnopharmacological relevance: Sequelae of pelvic inflammatory disease (SPID) occurs in female internal genitalia and surrounding connective tissue. Recent clinical studies have shown that the traditional Chinese medicine Fuke Qianjin capsule (FKQ) can shorten the course of this disease, but its pharmacological effects and potential mechanism have not been fully elucidated.

Aim of the study: This study aimed to investigate the efficacy and underlying mechanisms of FKQ in the treatment of SPID.

Methods: In this study, we first established a mixed infection model to explore the protective effect of FKQ on common pathogens of SPID. Afterwards, mixed bacterial infection and mechanical injury were used in a SPID rat model to explore the protective mechanism of FKQ on SPID rats. Inflammation, repair and immune cells were tested.

Results: FKQ has a protective effect against infections caused by SPID pathogenic bacterial and may reduce mortality from mixed infections. In the SPID model, FKQ improved pathological damage to the uterus, reduced the area of uterine fibrosis, and inhibited the levels of cytokines (TNF-α, IL-6, IL-1β, IL-18, TGF-β1 and VEGF) caused by pathogenic bacteria. Moreover, FKQ treatment reduced the accumulation of NLRP3, Caspase-1, GSDMD Vimentin, and Cytokeratin 18 in the uterus and suppressed the expression of TGF-β1 and VEGF in the fallopian tubes, thereby reducing inflammation and promoting mucosal repair. In addition, FKQ can restore the immune function balance of SPID rats by increasing the proportion of Treg cells in the spleen and thymus in a rat model of SPID, reducing the proportion of Th17 lymphocytes, and promoting an immunological balance of Treg/Th17 cells, thereby regulating the immune system of the body.

Conclusion: In summary, FKQ treatment for SPID is the result of a fourfold combination of antibacterial, anti-inflammatory, reparative and immune-enhancing activities.

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福克千金胶囊治疗盆腔炎后遗症的新思路：前期抗炎，后期修复。

民族药理学意义：盆腔炎（SPID）的后遗症发生在女性内生殖器和周围结缔组织。最近的临床研究表明，中药复方千金胶囊（FKQ）可缩短该病的病程，但其药理作用和潜在机制尚未完全阐明：本研究旨在探讨复方千金胶囊治疗SPID的疗效及其潜在机制：本研究首先建立了混合感染模型，探讨FKQ对SPID常见病原体的保护作用。方法：本研究首先建立了混合感染模型，探讨FKQ对SPID大鼠常见病原体的保护作用，然后在SPID大鼠模型中使用细菌混合感染和机械损伤，探讨FKQ对SPID大鼠的保护机制。结果显示：FKQ对SPID大鼠的炎症、修复和免疫细胞具有保护作用：结果：FKQ对SPID致病菌引起的感染具有保护作用，并可降低混合感染的死亡率。在 SPID 模型中，FKQ 改善了子宫的病理损伤，减少了子宫纤维化的面积，抑制了病原菌引起的细胞因子（TNF-α、IL-6、IL-1β、IL-18、TGF-β1 和 VEGF）水平。此外，FKQ 还能减少子宫中 NLRP3、Caspase-1、GSDMD Vimentin 和 Cytokeratin 18 的积累，抑制输卵管中 TGF-β1 和 VEGF 的表达，从而减轻炎症，促进粘膜修复。此外，FKQ还能恢复SPID大鼠的免疫功能平衡，增加SPID大鼠脾脏和胸腺中Treg细胞的比例，降低Th17淋巴细胞的比例，促进Treg/Th17细胞的免疫平衡，从而调节机体的免疫系统：总之，FKQ治疗SPID是抗菌、抗炎、修复和免疫增强四重作用相结合的结果。

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来源期刊

Journal of ethnopharmacology 医学-全科医学与补充医学

CiteScore

10.30

自引率

5.60%

发文量

967

审稿时长

77 days

期刊介绍： The Journal of Ethnopharmacology is dedicated to the exchange of information and understandings about people''s use of plants, fungi, animals, microorganisms and minerals and their biological and pharmacological effects based on the principles established through international conventions. Early people confronted with illness and disease, discovered a wealth of useful therapeutic agents in the plant and animal kingdoms. The empirical knowledge of these medicinal substances and their toxic potential was passed on by oral tradition and sometimes recorded in herbals and other texts on materia medica. Many valuable drugs of today (e.g., atropine, ephedrine, tubocurarine, digoxin, reserpine) came into use through the study of indigenous remedies. Chemists continue to use plant-derived drugs (e.g., morphine, taxol, physostigmine, quinidine, emetine) as prototypes in their attempts to develop more effective and less toxic medicinals.