Pressure-Induced Microvascular Reactivity With Whole Foot Loading Is Unique Across the Human Foot Sole.

IF 1.9 4区医学 Q3 HEMATOLOGY Microcirculation Pub Date : 2024-11-12 DOI:10.1111/micc.12893

Erika E Howe, Leah R Bent

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Abstract

Background: Foot sole plantar pressure generates transient but habitual cutaneous ischemia, which is even more exacerbated in atypical gait patterns. Thus, adequate post-occlusive reactive hyperaemia (PORH) is necessary to maintain skin health. Plantar pressure regional variance during daily tasks potentially generates region-specific PORH, crucial for ischemic defence.

Aims: The current work investigated regional PORH across the human foot sole resulting from stance-like loading.

Materials & methods: A loading device equipped with an in-line laser speckle contrast imager measured blood flux before, during, and after whole-foot loading for 2 and 10 min durations at 15% and 50% body weight. Flux was compared between six regions: the heel, lateral arch, medial arch, and fifth, third, and first metatarsals (MT).

Results: Baseline flux was significantly greater in the 1MT and 3MT than all other regions. Loading occluded the heel, 5MT and 3MT more than all other regions. Regional PORH peak, time to peak, area under the curve, and recovery rate were ranked between regions.

Discussion: The 3MT, followed by 5MT, overall had the strongest PORH response, suggesting a heightened protection against ischemia compared to other regions.

Conclusion: This work highlights regional variations within a healthy foot, providing a framework for future ulcer risk assessments and interventions to preserve foot health.

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全足加载时压力引起的微血管反应是人类足底独有的。

背景：足底足底压力会产生短暂但习惯性的皮肤缺血，这种缺血在非典型步态下会更加严重。因此，充分的闭塞后反应性高血症（PORH）是维持皮肤健康的必要条件。在日常工作中，足底压力的区域差异可能会产生特定区域的 PORH，这对于缺血防御至关重要：装有在线激光斑点对比成像仪的负重装置在体重为 15%和 50%、持续 2 分钟和 10 分钟的全足负重之前、期间和之后测量血流量。对六个区域的血流量进行了比较：足跟、足弓外侧、足弓内侧、第五、第三和第一跖骨（MT）：结果：第一跖骨和第三跖骨的基线通量明显高于所有其他区域。加载对脚跟、第五跖骨和第三跖骨的闭塞程度高于所有其他区域。各区域的 PORH 峰值、达到峰值的时间、曲线下面积和恢复率在各区域之间进行了排名：讨论：总体而言，3MT 的 PORH 反应最强，其次是 5MT，这表明与其他区域相比，3MT 对缺血的保护作用更强：这项研究强调了健康足部的区域差异，为未来的溃疡风险评估和保护足部健康的干预措施提供了框架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microcirculation 医学-外周血管病

CiteScore

5.00

自引率

4.20%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation. Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.

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