Review of the Anti-Candida albicans Activity and Physical Properties of Soft Lining Materials Modified with Polyene Antibiotics, Azole Drugs, and Chlorohexidine Salts.

IF 3.1 3区材料科学 Q3 CHEMISTRY, PHYSICAL Materials Pub Date : 2024-11-04 DOI:10.3390/ma17215383

Izabela Barszczewska-Rybarek, Patrycja Kula, Grzegorz Chladek

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Abstract

This review examined the current state of knowledge on the modifications of commercial soft lining materials (SLMs) with a variety of antifungal compounds: (i) polyene antibiotics, including nystatin and amphotericin B, (ii) azole drugs, including fluconazole, itraconazole, clotrimazole, ketoconazole, and miconazole, and (iii) antiseptics, including chlorhexidine salts to give them anti-Candida albicans properties. The effect of such modifications on the SLMs' physical properties, such as drug release, water sorption, surface properties, bond strength, tensile strength, and hardness, was also analyzed. In effect, this study provided a unique compilation of research results obtained for numerous properties of SLM modified with antifungal compounds that differ in their chemical structure and mechanism of antifungal action. These results might also be useful for prosthetic dentistry, where SLMs are used to prevent and treat candidiasis, the most common disease among denture wearers.

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用多烯抗生素、唑类药物和氯己定盐改性的软衬垫材料的抗白色念珠菌活性和物理性质综述

本综述研究了用各种抗真菌化合物对商用软衬里材料（SLMs）进行改性的知识现状：(i) 多烯类抗生素，包括硝司他丁和两性霉素 B；(ii) 唑类药物，包括氟康唑、伊曲康唑、克霉唑、酮康唑和咪康唑；(iii) 抗菌剂，包括洗必泰盐，使其具有抗白色念珠菌的特性。研究还分析了这些改性对 SLM 物理性质的影响，如药物释放、吸水性、表面性质、粘合强度、拉伸强度和硬度。实际上，这项研究提供了一份独特的研究成果汇编，其中汇集了用抗真菌化合物改性的 SLM 的多种特性，这些化合物的化学结构和抗真菌作用机制各不相同。这些结果可能对修复牙科也有帮助，因为 SLM 可用于预防和治疗义齿佩戴者最常见的念珠菌病。

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来源期刊

Materials MATERIALS SCIENCE, MULTIDISCIPLINARY-

CiteScore

5.80

自引率

14.70%

发文量

7753

审稿时长

1.2 months

期刊介绍： Materials (ISSN 1996-1944) is an open access journal of related scientific research and technology development. It publishes reviews, regular research papers (articles) and short communications. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Materials provides a forum for publishing papers which advance the in-depth understanding of the relationship between the structure, the properties or the functions of all kinds of materials. Chemical syntheses, chemical structures and mechanical, chemical, electronic, magnetic and optical properties and various applications will be considered.