Utility of icobrain for brain volumetry in multiple sclerosis clinical practice

IF 2.9 3区 医学 Q2 CLINICAL NEUROLOGY Multiple sclerosis and related disorders Pub Date : 2024-11-08 DOI:10.1016/j.msard.2024.106148
Ai-Lan Nguyen , Maria Pia Sormani , Dana Horakova , Eva H Havrdova , Michael H Barnett , Nicola De Stefano , Marco Battaglini , Manuela Vaneckova , Elaine Lui , Frank Gaillard , Patricia M Desmond , Hayden Prime , Mineesh Datta , Anneke Van der Walt , Vilija G Jokubaitis , Femke Podevyn , Robert Zivadinov , Bianca Weinstock-Guttman , Marie B D'hooghe , Guy Nagels , Helmut Butzkueven
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Abstract

Background

Few studies on multiple sclerosis (MS) have explored the variability of percentage brain volume change (PBVC) measurements obtained from different clinical MRIs. In a retrospective multicentre cohort study, we quantified the variability of annualised PBVC in clinical MRIs.

Methods

Clinical MRIs of relapse-onset MS patients were assessed by icobrain. Volumetric data were analysed on same-scanner and different-scanner MRI pairs if they passed quality control criteria. Alignment similarity between two images had to be comparable to same-scanner scan-rescan images.

Results

Of 6826 MRIs, 85 % had appropriate volumetric sequences and 4446 serial MRI pairs were analysed. 3334 (75 %) MRI pairs from 1207 patients met the inclusions. The PBVC of included MRI pairs showed variance of 0.78 % for same-scanner pairs and 0.80 % for different-scanner pairs. Further selection of included MRI pairs with the best variance resulted in 1885 (42 %) MRI pairs with PBVC variance of 0.34 %. Excluded MRI pairs with poor alignment similarity had variances of 2.97 % for same-scanner pairs and 20.79 % for different-scanner pairs.

Conclusion

Icobrain should be utilised for PBVC determination only on selected MRIs with the best alignment similarity. Applying strict selection criteria for the included MRI pairs and longitudinal imaging on the same scanner remain mandatory to reduce PBVC variability.
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icobrain 在多发性硬化症临床实践中对脑容量测量的实用性。
背景:有关多发性硬化症(MS)的研究很少探讨从不同临床磁共振成像中获得的脑容量变化百分比(PBVC)测量值的变异性。在一项回顾性多中心队列研究中,我们量化了临床核磁共振成像中年化脑容量变化百分比的变异性:复发多发性硬化症患者的临床磁共振成像由 icobrain 评估。如果通过了质量控制标准,则对同一扫描仪和不同扫描仪的核磁共振成像对的容积数据进行分析。两张图像之间的对齐相似度必须与同扫描仪扫描-再扫描图像相当:在 6826 例磁共振成像中,85% 有适当的容积序列,4446 对序列磁共振成像进行了分析。来自 1207 名患者的 3334 对(75%)核磁共振成像符合纳入标准。纳入的磁共振成像对的 PBVC 显示,同扫描仪成像对的方差为 0.78%,不同扫描仪成像对的方差为 0.80%。进一步选择方差最佳的纳入磁共振成像对后,1885 对(42%)磁共振成像对的 PBVC 方差为 0.34%。排除了配准相似性较差的磁共振成像对,同扫描仪对的方差为 2.97 %,不同扫描仪对的方差为 20.79 %:结论:Icobrain 只应在选定的具有最佳配准相似性的 MRI 上用于 PBVC 测定。要降低 PBVC 变异性,必须对纳入的 MRI 成对应用严格的选择标准,并在同一扫描仪上进行纵向成像。
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来源期刊
CiteScore
5.80
自引率
20.00%
发文量
814
审稿时长
66 days
期刊介绍: Multiple Sclerosis is an area of ever expanding research and escalating publications. Multiple Sclerosis and Related Disorders is a wide ranging international journal supported by key researchers from all neuroscience domains that focus on MS and associated disease of the central nervous system. The primary aim of this new journal is the rapid publication of high quality original research in the field. Important secondary aims will be timely updates and editorials on important scientific and clinical care advances, controversies in the field, and invited opinion articles from current thought leaders on topical issues. One section of the journal will focus on teaching, written to enhance the practice of community and academic neurologists involved in the care of MS patients. Summaries of key articles written for a lay audience will be provided as an on-line resource. A team of four chief editors is supported by leading section editors who will commission and appraise original and review articles concerning: clinical neurology, neuroimaging, neuropathology, neuroepidemiology, therapeutics, genetics / transcriptomics, experimental models, neuroimmunology, biomarkers, neuropsychology, neurorehabilitation, measurement scales, teaching, neuroethics and lay communication.
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