A Longer Biliopancreatic Limb and Shorter Common Channel Enhance Weight Loss But May Have Harmful Effects in Mouse Models of Roux-en-Y Gastric Bypass.

IF 2.9 3区医学 Q1 SURGERY Obesity Surgery Pub Date : 2024-11-09 DOI:10.1007/s11695-024-07578-7

Raymond Lau, Matthew Stevenson, Munichandra Babu Tirumalasetty, Jenny Lee, Christopher Hall, Qing Miao, Collin Brathwaite, Louis Ragolia

{"title":"A Longer Biliopancreatic Limb and Shorter Common Channel Enhance Weight Loss But May Have Harmful Effects in Mouse Models of Roux-en-Y Gastric Bypass.","authors":"Raymond Lau, Matthew Stevenson, Munichandra Babu Tirumalasetty, Jenny Lee, Christopher Hall, Qing Miao, Collin Brathwaite, Louis Ragolia","doi":"10.1007/s11695-024-07578-7","DOIUrl":null,"url":null,"abstract":"Background: RYGB consists of the Roux limb (RL), the biliopancreatic limb (BPL), and the common channel (CC). There is no consensus on the optimal limb lengths.Methods: Using a mouse model of RYGB, 30 diet-induced obese mice were divided into two groups with varying BPL and CC lengths: a standard BPL with a long CC (RYGB S) and a long BPL with a short CC (RYGB L). Additionally, 9 age-matched, lean control mice (LC) were also included in this study.Results: RYGB S had limb lengths of RL = 17%, BPL = 24%, and CC = 59%. RYGB L had limb lengths of RL = 17%, BPL = 32%, and CC = 51%. RYGB S and RYGB L had 67% and 40% survival, respectively. Mortality in RYGB L included more instances where the cause of death was not apparent. RYGB L demonstrated greater weight loss, lower energy expenditure, and lower heart mass as compared to RYGB S. Both RYGB groups had lower epidydimal fat mass, spleen mass, and bone mineral density compared to LC. RYGB L had a lower heart mass than RYGB S and LC. While the relative abundance of Eubacterium was lower in RYGB L than in RYGB S, no other gut microbiota differences were observed.Conclusions: A longer BPL with a shorter CC induces greater weight loss but may lead to adverse effects, including lower heart mass, reduced bone density, and deaths with unclear causes.","PeriodicalId":19460,"journal":{"name":"Obesity Surgery","volume":" ","pages":""},"PeriodicalIF":2.9000,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Obesity Surgery","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11695-024-07578-7","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"SURGERY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: RYGB consists of the Roux limb (RL), the biliopancreatic limb (BPL), and the common channel (CC). There is no consensus on the optimal limb lengths.

Methods: Using a mouse model of RYGB, 30 diet-induced obese mice were divided into two groups with varying BPL and CC lengths: a standard BPL with a long CC (RYGB S) and a long BPL with a short CC (RYGB L). Additionally, 9 age-matched, lean control mice (LC) were also included in this study.

Results: RYGB S had limb lengths of RL = 17%, BPL = 24%, and CC = 59%. RYGB L had limb lengths of RL = 17%, BPL = 32%, and CC = 51%. RYGB S and RYGB L had 67% and 40% survival, respectively. Mortality in RYGB L included more instances where the cause of death was not apparent. RYGB L demonstrated greater weight loss, lower energy expenditure, and lower heart mass as compared to RYGB S. Both RYGB groups had lower epidydimal fat mass, spleen mass, and bone mineral density compared to LC. RYGB L had a lower heart mass than RYGB S and LC. While the relative abundance of Eubacterium was lower in RYGB L than in RYGB S, no other gut microbiota differences were observed.

Conclusions: A longer BPL with a shorter CC induces greater weight loss but may lead to adverse effects, including lower heart mass, reduced bone density, and deaths with unclear causes.

查看原文

微信好友朋友圈 QQ好友复制链接

本刊更多论文

较长的胰胆管肢体和较短的共同通道可增强鲁氏胃旁路术小鼠模型的减肥效果，但可能会产生有害影响。

背景：RYGB 包括鲁克斯瓣（RL）、胆胰瓣（BPL）和共同通道（CC）。关于最佳肢体长度还没有达成共识：方法：利用小鼠 RYGB 模型，将 30 只饮食诱导肥胖小鼠分为两组，两组的 BPL 和 CC 长度各不相同：标准 BPL 长 CC 组（RYGB S）和长 BPL 短 CC 组（RYGB L）。此外，本研究还包括 9 只年龄匹配的瘦对照组小鼠（LC）：结果：RYGB S 的肢长为 RL = 17%、BPL = 24% 和 CC = 59%。RYGB L 的肢长为 RL = 17%、BPL = 32% 和 CC = 51%。RYGB S 和 RYGB L 的存活率分别为 67% 和 40%。RYGB L 的死亡率包括更多死因不明的病例。与 LC 相比，RYGB L 组的体重减轻幅度更大，能量消耗更低，心脏质量更低。RYGB L 组的心脏质量低于 RYGB S 组和 LC 组。虽然 RYGB L 组的 Eubacterium 相对丰度低于 RYGB S 组，但未观察到其他肠道微生物群差异：结论：较长的 BPL 和较短的 CC 可使体重减轻，但可能会导致不良影响，包括心脏质量降低、骨密度降低和死因不明。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文去求助

来源期刊

Obesity Surgery 医学-外科

CiteScore

5.80

自引率

24.10%

发文量

567

审稿时长

3-6 weeks

期刊介绍： Obesity Surgery is the official journal of the International Federation for the Surgery of Obesity and metabolic disorders (IFSO). A journal for bariatric/metabolic surgeons, Obesity Surgery provides an international, interdisciplinary forum for communicating the latest research, surgical and laparoscopic techniques, for treatment of massive obesity and metabolic disorders. Topics covered include original research, clinical reports, current status, guidelines, historical notes, invited commentaries, letters to the editor, medicolegal issues, meeting abstracts, modern surgery/technical innovations, new concepts, reviews, scholarly presentations and opinions. Obesity Surgery benefits surgeons performing obesity/metabolic surgery, general surgeons and surgical residents, endoscopists, anesthetists, support staff, nurses, dietitians, psychiatrists, psychologists, plastic surgeons, internists including endocrinologists and diabetologists, nutritional scientists, and those dealing with eating disorders.