Clinical Control and Quality of Life in Patients With Chronic Rhinosinusitis With Asthma: A Study on the Effects of Endoscopic Sinus Surgery.

IF 2.6 3区医学 Q1 OTORHINOLARYNGOLOGY Otolaryngology- Head and Neck Surgery Pub Date : 2024-11-12 DOI:10.1002/ohn.1040

Rongfeng Ma

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Abstract

Objective: To determine the impact of endoscopic sinus surgery (ESS) on chronic rhinosinusitis with asthma (CRSwA) patients' clinical control and quality of life.

Study design: A randomized controlled trial involving 150 CRSwA patients, equally divided into surgical and control groups.

Setting: Participants were matched for age, gender, illness duration, and computed tomography (CT) grading of the sinuses.

Methods: Random allocation was conducted using a computer-generated table.

Results: The surgical group exhibited significant symptom score improvements across all metrics (P < .001). Lung function parameters showed substantial gains, with forced expiratory volume in 1 second (FEV1), forced vital capacity (FVC), and FEV1/FVC ratios significantly higher than the control group (P < .001). Quality of life scores, measured by RQLQ and AQLQ, improved significantly in the surgical group (P < .001). At 6 months, correlations between lung function and CT grading of the sinuses were evident, with negative and positive correlations, respectively (P < .05). Inflammatory markers and medication usage were notably reduced (P < .001, P < .05), with low adverse event rates (1%).

Conclusion: ESS is effective in enhancing clinical outcomes and quality of life for CRSwA patients, reducing inflammation and medication needs, thus supporting its use as a beneficial treatment.

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慢性鼻窦炎合并哮喘患者的临床控制和生活质量：关于内窥镜鼻窦手术效果的研究。

研究目的确定内窥镜鼻窦手术（ESS）对慢性鼻窦炎合并哮喘（CRSwA）患者的临床控制和生活质量的影响：随机对照试验：150 名慢性鼻窦炎合并哮喘（CRSwA）患者参加，平均分为手术组和对照组：参与者的年龄、性别、病程和鼻窦计算机断层扫描（CT）分级均匹配：方法：使用计算机生成的表格进行随机分配：结果：手术组在所有指标上的症状评分均有明显改善（P 结论：ESS 能有效提高临床疗效：ESS能有效提高CRSwA患者的临床疗效和生活质量，减少炎症和药物需求，因此支持将其作为一种有益的治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Otolaryngology- Head and Neck Surgery 医学-耳鼻喉科学

CiteScore

6.70

自引率

2.90%

发文量

250

审稿时长

2-4 weeks

期刊介绍： Otolaryngology–Head and Neck Surgery (OTO-HNS) is the official peer-reviewed publication of the American Academy of Otolaryngology–Head and Neck Surgery Foundation. The mission of Otolaryngology–Head and Neck Surgery is to publish contemporary, ethical, clinically relevant information in otolaryngology, head and neck surgery (ear, nose, throat, head, and neck disorders) that can be used by otolaryngologists, clinicians, scientists, and specialists to improve patient care and public health.