Nosemosis negatively affects honeybee survival: experimental and meta-analytic evidence.

IF 2.1 3区 医学 Q2 PARASITOLOGY Parasitology Pub Date : 2024-11-15 DOI:10.1017/S0031182024001446
Monika Ostap-Chec, Jessica Cait, R Wilder Scott, Aneta Arct, Dawid Moroń, Marcin Rapacz, Krzysztof Miler
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Abstract

Nosemosis, caused by microsporidian parasites of the genus Nosema, is considered a significant health concern for insect pollinators, including the economically important honeybee (Apis mellifera). Despite its acknowledged importance, the impact of this disease on honeybee survivorship remains unclear. Here, a standard laboratory cage trial was used to compare mortality rates between healthy and Nosema-infected honeybees. Additionally, a systematic review and meta-analysis of existing literature were conducted to explore how nosemosis contributes to increased mortality in honeybees tested under standard conditions. The review and meta-analysis included 50 studies that reported relevant experiments involving healthy and Nosema-infected individuals. Studies lacking survivorship curves or information on potential moderators, such as spore inoculation dose, age of inoculated bees, or factors that may impact energy expenditure, were excluded. Both the experimental results and meta-analysis revealed a consistent, robust effect of infection, indicating a threefold increase in mortality among the infected group of honeybee workers (hazard ratio for infected individuals = 3.16 [1.97–5.07] and 2.99 [2.36–3.79] in the experiment and meta-analysis, respectively). However, the meta-analysis also indicated high heterogeneity in the effect magnitude, which was not explained by our moderators. Furthermore, there was a serious risk of bias within studies and potential publication bias across studies. The findings underscore knowledge gaps in the literature. It is stressed that laboratory cage trials should be viewed as an initial step in evaluating the impact of Nosema on mortality and that complementary field and apiary studies are essential for identifying effective treatments to preserve honeybee populations.

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鼻疽对蜜蜂存活率的负面影响:实验和元分析证据。
微孢子虫病是由微孢子虫属寄生虫引起的,被认为是昆虫传粉媒介的重大健康问题,包括具有重要经济意义的蜜蜂。尽管它的重要性得到公认,但这种疾病对蜜蜂生存的影响仍不清楚。在这里,一个标准的实验室笼试验被用来比较健康和感染微虫的蜜蜂的死亡率。此外,对现有文献进行了系统回顾和荟萃分析,以探讨在标准条件下,鼻塞病如何导致蜜蜂死亡率增加。该综述和荟萃分析包括50项研究,这些研究报告了涉及健康和感染诺塞马的个体的相关实验。排除了缺乏生存曲线或潜在调节因子信息的研究,如孢子接种剂量、接种蜜蜂的年龄或可能影响能量消耗的因素。实验结果和荟萃分析都显示了一致的、强大的感染效应,表明感染组的蜜蜂工蜂死亡率增加了三倍(实验和荟萃分析中感染个体的风险比分别为3.16[1.97-5.07]和2.99[2.36-3.79])。然而,荟萃分析也表明,影响程度的异质性很高,我们的调节因子无法解释这一点。此外,研究内部存在严重的偏倚风险,研究之间存在潜在的发表偏倚。这些发现强调了文献中的知识缺口。需要强调的是,实验室笼试验应被视为评估小虫病对死亡率影响的第一步,补充性的现场和养蜂场研究对于确定保护蜜蜂种群的有效治疗方法至关重要。
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来源期刊
Parasitology
Parasitology 医学-寄生虫学
CiteScore
4.80
自引率
4.20%
发文量
280
审稿时长
3-8 weeks
期刊介绍: Parasitology is an important specialist journal covering the latest advances in the subject. It publishes original research and review papers on all aspects of parasitology and host-parasite relationships, including the latest discoveries in parasite biochemistry, molecular biology and genetics, ecology and epidemiology in the context of the biological, medical and veterinary sciences. Included in the subscription price are two special issues which contain reviews of current hot topics, one of which is the proceedings of the annual Symposia of the British Society for Parasitology, while the second, covering areas of significant topical interest, is commissioned by the editors and the editorial board.
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