Deep Myometrial Infiltration leads to a measurable Inflammatory Response in Endometrial Cancer. A Prospective Observational Study.

IF 3 3区医学 Q2 ONCOLOGY Seminars in oncology Pub Date : 2024-10-23 DOI:10.1053/j.seminoncol.2024.10.002

Carlo Ronsini, Irene Iavarone, Eleonora Braca, Maria Giovanna Vastarella, Luigi Della Corte, Clorinda Vitale, Giada Andreoli, Elvira La Mantia, Luigi Cobellis, Pasquale de Franciscis

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Abstract

Backgrounds: This study aims to evaluate the correlation between inflammation indices, such as neutrophil-lymphocyte ratio (NLR), monocyte-lymphocyte ratio (MLR), platelet-lymphocyte ratio (PLR) and deep myometrial infiltration (≥50%) prospectively in patients with endometrial carcinoma, providing insights into the interaction between these parameters MATERIAL AND METHODS: A prospective observational cohort study was conducted at AOU Vanvitelli in Naples, Italy, from August 2023 to March 2024. Data from 161 patients undergoing surgery for endometrial cancer, including preoperative blood counts and histopathological information, were collected. Statistical analyses were performed using R software.

Results: After logistic regression, NLR and MLR showed a statistically significant association with deep myometrial infiltration (NLR log(OR) 0.15, P = .040; MLR log(OR) 0.30, P = .008). However, after multivariate logistic regression which included other risk factors such as grading, histotype, and MSI only NLR retained statistical significance, (Log(Or) 0.18, P = .031).

Conclusion: Our results demonstrate noticeable changes in inflammation indices associated with deep myometrial infiltration in endometrial carcinoma. Moreover, a correlation between NLR and deep myometrial infiltration exists regardless of microsatellite instability, histotype, and grading.

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深层子宫肌层浸润导致子宫内膜癌出现可测量的炎症反应。前瞻性观察研究。

背景：本研究旨在前瞻性地评估子宫内膜癌患者的中性粒细胞-淋巴细胞比值（NLR）、单核细胞-淋巴细胞比值（MLR）、血小板-淋巴细胞比值（PLR）等炎症指数与子宫深部肌层浸润（≥50%）之间的相关性，从而深入了解这些参数之间的相互作用。材料与方法：2023 年 8 月至 2024 年 3 月，意大利那不勒斯 AOU Vanvitelli 医院开展了一项前瞻性观察性队列研究：2023 年 8 月至 2024 年 3 月，意大利那不勒斯 AOU Vanvitelli 医院开展了一项前瞻性观察性队列研究。研究收集了 161 名接受子宫内膜癌手术患者的数据，包括术前血细胞计数和组织病理学信息。统计分析使用 R 软件进行：经过逻辑回归，NLR和MLR与子宫深部肌层浸润有显著的统计学关联（NLR log(OR) 0.15，P = .040；MLR log(OR) 0.30，P = .008）。然而，在包括分级、组织型和 MSI 等其他风险因素的多变量逻辑回归后，只有 NLR 仍具有统计学意义（Log(Or) 0.18，P = .031）：我们的研究结果表明，子宫内膜癌的炎症指数发生了明显变化，这与子宫内膜癌的深部肌层浸润有关。此外，无论微卫星不稳定性、组织型和分级如何，NLR 与子宫深部肌层浸润之间都存在相关性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Seminars in oncology 医学-肿瘤学

CiteScore

6.60

自引率

0.00%

发文量

审稿时长

104 days

期刊介绍： Seminars in Oncology brings you current, authoritative, and practical reviews of developments in the etiology, diagnosis and management of cancer. Each issue examines topics of clinical importance, with an emphasis on providing both the basic knowledge needed to better understand a topic as well as evidence-based opinions from leaders in the field. Seminars in Oncology also seeks to be a venue for sharing a diversity of opinions including those that might be considered "outside the box". We welcome a healthy and respectful exchange of opinions and urge you to approach us with your insights as well as suggestions of topics that you deem worthy of coverage. By helping the reader understand the basic biology and the therapy of cancer as they learn the nuances from experts, all in a journal that encourages the exchange of ideas we aim to help move the treatment of cancer forward.