"The Association between Vitamin D Deficiency and Childhood Obesity and Its Impact on Children's Serum Calcium, Alkaline Phosphatase, and Bone Age".

IF 2.5 3区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Prostaglandins & other lipid mediators Pub Date : 2024-11-07 DOI:10.1016/j.prostaglandins.2024.106920

Juanjuan Zhu, Bingbing Wang, Sanaz Asemani, Shiwei Bao, Niannian Tian

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引用次数: 0

Abstract

Objective: The research aimed to investigate the Association between Vitamin D deficiency and childhood obesity and its Impact on children's serum calcium, alkaline Phosphatase, and bone Age METHODS: The study analyzed clinical data from 159 school-aged children who underwent medical examinations. The children were divided into a 25-(OH)D3 deficiency group and a non-25-(OH)D3 deficiency group based on their serum 25-hydroxy Vitamin D3 levels. The two groups were compared regarding BMI, TC, TG, FBG, HbA1c, Ca, ALP, and bone age differences.

Results: Individuals with a deficiency in 25-(OH)D3 exhibited higher levels of BMI, TC, TG, and ALP, and lower levels of Ca and bone age than those without the deficiency. These differences were statistically significant (P<0.05). Further analysis revealed a negative association between 25-(OH)D3 levelsa positive correlation between Ca and bone age, and a positive correlation with, BMI, TC, TG, and ALP.

Conclusion: The deficiency of 25-(OH)D3 in school-aged children is linked to obesity and impacts bone growth. Monitoring vitamin D levels is crucial for clinical practitioners.

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"维生素 D 缺乏与儿童肥胖之间的关联及其对儿童血清钙、碱性磷酸酶和骨龄的影响"。

研究目的研究旨在探讨维生素 D 缺乏与儿童肥胖之间的关联及其对儿童血清钙、碱性磷酸酶和骨龄的影响方法：研究分析了 159 名接受体检的学龄儿童的临床数据。根据儿童血清中 25- 羟基维生素 D3 的水平，将其分为 25-(OH)D3 缺乏组和非 25-(OH)D3 缺乏组。两组儿童的体重指数（BMI）、总胆固醇（TC）、总胆固醇（TG）、血糖（FBG）、糖化血红蛋白（HbA1c）、钙（Ca）、谷丙转氨酶（ALP）和骨龄差异进行了比较：结果：与缺乏 25-(OH)D3 的人相比，缺乏 25-(OH)D3 的人的 BMI、TC、TG 和 ALP 水平较高，而 Ca 和骨龄水平较低。这些差异具有统计学意义（PC结论：学龄儿童缺乏 25-(OH)D3 与肥胖有关，并影响骨骼生长。监测维生素 D 水平对临床医师至关重要。

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来源期刊

Prostaglandins & other lipid mediators 生物-生化与分子生物学

CiteScore

5.80

自引率

3.40%

发文量

审稿时长

2 months

期刊介绍： Prostaglandins & Other Lipid Mediators is the original and foremost journal dealing with prostaglandins and related lipid mediator substances. It includes basic and clinical studies related to the pharmacology, physiology, pathology and biochemistry of lipid mediators. Prostaglandins & Other Lipid Mediators invites reports of original research, mini-reviews, reviews, and methods articles in the basic and clinical aspects of all areas of lipid mediator research: cell biology, developmental biology, genetics, molecular biology, chemistry, biochemistry, physiology, pharmacology, endocrinology, biology, the medical sciences, and epidemiology. Prostaglandins & Other Lipid Mediators also accepts proposals for special issue topics. The Editors will make every effort to advise authors of the decision on the submitted manuscript within 3-4 weeks of receipt.