Model Organoids: Integrated Frameworks for the Next Frontier of Healthcare Advancements.

IF 4.5 3区医学 Q2 CELL & TISSUE ENGINEERING Stem Cell Reviews and Reports Pub Date : 2024-11-11 DOI:10.1007/s12015-024-10814-3

Riya Bhattacharya, Debajyoti Bose, Tanveen Kaur, Rushik Patel, Oladri Renuka, Raul V Rodriguez

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Abstract

The morphogenetic events leading to tissue formation can be recapitulated using organoids, which allows studying new diseases and modelling personalized medicines. In this review, culture systems comparable to human organs are presented, these organoids are created from pluripotent stem cells or adult stem cells. The efficient and reproducible models of human tissues are discussed for biobanking, precision medicine and basic research. Mechanisms used by these model systems with an overview of models from human cells are also covered. As human physiology is different from animals, culture conditions and tissue limits often become challenging. Organoids offer novel approaches for such cases with rapid screening, transplantation studies and in immunotherapy. Discrepancies with large datasets can be handled with an integrated framework of artificial intelligence or AI and machine learning. An attempt has been made to show the improved effectiveness, simplified iterations, along with image analysis that are possible from this synergy. AI-assisted organoids have the potential to transform healthcare by improving disease understanding and accelerating clinical decision-making through personalized and precision medicine.

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器官模型：下一个医疗进步前沿的综合框架。

利用器官组织可以重现导致组织形成的形态发生过程，这有助于研究新疾病和建立个性化药物模型。本综述介绍了与人体器官相媲美的培养系统，这些器官组织是由多能干细胞或成人干细胞创建的。讨论了用于生物库、精准医疗和基础研究的高效、可重复的人体组织模型。此外，还介绍了这些模型系统所使用的机制，并概述了来自人类细胞的模型。由于人体生理学与动物不同，培养条件和组织限制往往具有挑战性。在这种情况下，有机体为快速筛选、移植研究和免疫疗法提供了新的方法。大型数据集的差异可以通过人工智能或人工智能与机器学习的综合框架来处理。我们试图展示这种协同作用所能带来的效果提升、迭代简化以及图像分析。人工智能辅助器官组织有可能通过个性化和精准医疗改善对疾病的理解并加速临床决策，从而改变医疗保健。

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来源期刊

Stem Cell Reviews and Reports 医学-细胞生物学

CiteScore

9.30

自引率

4.20%

发文量

审稿时长

3 months

期刊介绍： The purpose of Stem Cell Reviews and Reports is to cover contemporary and emerging areas in stem cell research and regenerative medicine. The journal will consider for publication: i) solicited or unsolicited reviews of topical areas of stem cell biology that highlight, critique and synthesize recent important findings in the field. ii) full length and short reports presenting original experimental work. iii) translational stem cell studies describing results of clinical trials using stem cells as therapeutics. iv) papers focused on diseases of stem cells. v) hypothesis and commentary articles as opinion-based pieces in which authors can propose a new theory, interpretation of a controversial area in stem cell biology, or a stem cell biology question or paradigm. These articles contain more speculation than reviews, but they should be based on solid rationale. vi) protocols as peer-reviewed procedures that provide step-by-step descriptions, outlined in sufficient detail, so that both experts and novices can apply them to their own research. vii) letters to the editor and correspondence. In order to facilitate this exchange of scientific information and exciting novel ideas, the journal has created five thematic sections, focusing on: i) the role of adult stem cells in tissue regeneration; ii) progress in research on induced pluripotent stem cells, embryonic stem cells and mechanism governing embryogenesis and tissue development; iii) the role of microenvironment and extracellular microvesicles in directing the fate of stem cells; iv) mechanisms of stem cell trafficking, stem cell mobilization and homing with special emphasis on hematopoiesis; v) the role of stem cells in aging processes and cancerogenesis.