RISK OF INSUFFICIENT HYDROXYVITAMIN D LEVELS IN DIABETIC FOOT ULCERS IN RIVERS STATE NIGERIA.

Abstract

Background: The global increase in diabetes, especially in developing nations, has escalated complications like diabetic foot ulcers. Hypovitaminosis D is considerably prevalent among individuals with Type 2 Diabetes Mellitus (T2DM), especially among those with chronic vascular complications.

Objectives: To determine the association between vitamin D levels and foot ulcers among patients with T2DM.

Methods: The study population comprised of 176 individuals (88 individuals with diabetic foot ulcers (DFUs) and 88 individuals with T2DM without DFU). Vitamin D levels were assessed using blood samples according to standard methods.

Results: The majority of participants in the DFU group presented with Grade 2 and Grade 3 ulcers. There was a significant difference in serum vitamin D levels, indicating lower levels among cases (mean of 19.6 ng/ml ± 13.6) compared to controls (mean of 36.2 ng/ml ± 11.4) with a p-value of 0.014. Data shows 84.1% of persons with foot ulcers had deficient/insufficient vitamin D, while only 29.5% of persons without DFU had deficient/insufficient vitamin D levels. Regression analysis shows that persons with DFU were 12.6 (6.0 - 26.2) times likely to have deficient/insufficient vitamin D levels. Chi-square analysis shows that the distribution of the DFU severity was significantly higher among persons with deficient Vitamin D levels, compared to persons with sufficient Vitamin D levels (p = 0.0001).

Conclusion: Lower serum vitamin D levels are significantly associated with diabetic foot ulcers (DFUs), potentially hindering healing and immune function. Screening for and correcting vitamin D deficiency may potentially improve the outcome in patients with diabetic foot ulcers.