Association of COVID-19 With Risk of Posttransplant Diabetes Mellitus.

IF 5.3 2区医学 Q1 IMMUNOLOGY Transplantation Pub Date : 2024-11-06 DOI:10.1097/TP.0000000000005227

Amanda J Vinson, A Jerrod Anzalone, Makayla Schissel, Ran Dai, Amy L Olex, Roslyn B Mannon

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Abstract

Background: Posttransplant diabetes mellitus (PTDM) is an important complication for solid organ transplant recipients (SOTRs). COVID-19 has been associated with an increased risk of incident diabetes in the general population. However, the association between COVID-19 and new-onset PTDM has not been explored.

Methods: Using the National COVID Cohort Collaborative Enclave, we conducted a cohort study of adults without diabetes receiving a solid organ transplant (heart, lung, kidney, or liver) in the United States between April 1, 2020, and March 31, 2023, with and without a first diagnosis of COVID-19 (COVID+ versus COVID-) within 180 d of SOT. We propensity score matched a single COVID+ SOTR with a COVID- SOTR who was diabetes free at the same point posttransplant. Within this matched cohort, we used multivariable Cox proportional hazards models to examine the adjusted risk of PTDM associated with COVID+.

Results: Among 1342 COVID+ SOTRs matched to 1342 COVID- SOTRs, the crude rate of newly diagnosed PTDM in the 2 y post-COVID was 17% in those with versus 13% in those without COVID-19 (P = 0.007). COVID-19 was significantly associated with new PTDM (adjusted hazard ratio, 1.37; 95% confidence interval, 1.12-1.68 at 2 y).

Conclusions: Similar to other viral infections, COVID-19 is associated with an increased risk of PTDM in SOTRs.

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COVID-19与移植后糖尿病风险的关系

背景：移植后糖尿病（PTDM）是实体器官移植受者（SOTR）的一个重要并发症。在普通人群中，COVID-19 与糖尿病发病风险增加有关。然而，COVID-19与新发PTDM之间的关联尚未得到探讨：我们利用国家 COVID 队列合作飞地，对 2020 年 4 月 1 日至 2023 年 3 月 31 日期间在美国接受实体器官移植（心脏、肺、肾脏或肝脏）的无糖尿病成人进行了一项队列研究，研究对象包括在 SOT 后 180 天内首次诊断出 COVID-19 （COVID+ 与 COVID-）的人和未诊断出 COVID-19 的人。我们将单个 COVID+ SOTR 与移植后同一时间无糖尿病的 COVID- SOTR 进行倾向评分匹配。在这个匹配队列中，我们使用多变量考克斯比例危险模型来检验与 COVID+ 相关的 PTDM 调整后风险：结果：在与 1342 名 COVID+ SOTR 匹配的 SOTR 中，COVID-19 患者在 COVID 后 2 年内新诊断出 PTDM 的粗略比率为 17%，而 COVID-19 患者为 13%（P = 0.007）。COVID-19与新发PTDM明显相关（2年内调整后危险比为1.37；95%置信区间为1.12-1.68）：结论：与其他病毒感染相似，COVID-19 与 SOTRs PTDM 风险增加有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Transplantation 医学-免疫学

CiteScore

8.50

自引率

11.30%

发文量

1906

审稿时长

1 months

期刊介绍： The official journal of The Transplantation Society, and the International Liver Transplantation Society, Transplantation is published monthly and is the most cited and influential journal in the field, with more than 25,000 citations per year. Transplantation has been the trusted source for extensive and timely coverage of the most important advances in transplantation for over 50 years. The Editors and Editorial Board are an international group of research and clinical leaders that includes many pioneers of the field, representing a diverse range of areas of expertise. This capable editorial team provides thoughtful and thorough peer review, and delivers rapid, careful and insightful editorial evaluation of all manuscripts submitted to the journal. Transplantation is committed to rapid review and publication. The journal remains competitive with a time to first decision of fewer than 21 days. Transplantation was the first in the field to offer CME credit to its peer reviewers for reviews completed. The journal publishes original research articles in original clinical science and original basic science. Short reports bring attention to research at the forefront of the field. Other areas covered include cell therapy and islet transplantation, immunobiology and genomics, and xenotransplantation.