Atomized inhalation of indocyanine green in thoracoscopic surgery for intralobar pulmonary sequestration: a multicenter study.

IF 5.8 2区 医学 Q1 Medicine Respiratory Research Pub Date : 2024-11-10 DOI:10.1186/s12931-024-03024-5
Ye Yin, Guofeng Zhang, Wei Li, Didi Zhuansun, Xiaofeng Xiong, Yanan Li, Yin He, Wenjing Wang, Tianqi Zhu, Jiexiong Feng
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Abstract

Background: Investigate the safety and efficacy of preoperative atomization inhalation of indocyanine green (ICG) solution in precise lesion resection of pediatric thoracoscopic intralobar pulmonary sequestration.

Methods: A multicenter 1:1 matched case-control study was adopted, to compare the safety and efficacy of the ICG group (preoperative atomization inhalation of 0.5 mg/kg ICG solution) with traditional group (no preoperative atomization inhalation of ICG solution). The baseline, intraoperative, and postoperative recovery conditions of the two groups were observed. Outpatient follow-up visits were conducted 3 to 6 months after surgery, including lung CT scans and pulmonary ventilation function tests.

Results: 134 patients were included in the study. The ICG group included 67 patients, and the traditional surgery group included 67 patients matched at a ratio of 1:1 according to age and lesion location. There were no reports of deaths or adverse reactions. The postoperative chest drainage tube indwelling time [(53.19 ± 8.15) hours vs. (73.25 ± 15.51) hours, P < 0.001] and postoperative hospital stay [(4.81 ± 1.84) days vs. (6.72 ± 1.31) days, P < 0.001] were shorter in the ICG group than in the traditional group. More importantly, the postoperative pulmonary function in the ICG group was better than that in the traditional group. No residual lesions were found in the postoperative CT examination of both groups.

Conclusions: The innovative application of atomization inhalation of ICG provides the possibility for precise localization and lesion resection of pediatric thoracoscopic intralobar pulmonary sequestration. This maximizes the preservation of normal lung parenchyma, better improves postoperative pulmonary function, and shortens postoperative recovery time.

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在胸腔镜手术中雾化吸入吲哚菁绿治疗肺内封堵:一项多中心研究。
背景:探讨术前雾化吸入吲哚菁绿(ICG)溶液在小儿胸腔镜下肺动脉内嵌塞精确病灶切除术中的安全性和有效性:采用多中心1:1匹配病例对照研究,比较ICG组(术前雾化吸入0.5 mg/kg ICG溶液)与传统组(术前不雾化吸入ICG溶液)的安全性和有效性。观察了两组的基线、术中和术后恢复情况。术后 3 至 6 个月进行门诊随访,包括肺 CT 扫描和肺通气功能测试:研究共纳入 134 名患者。ICG组包括67名患者,传统手术组包括67名患者,两组患者的年龄和病变位置比例为1:1。无死亡或不良反应报告。术后胸腔引流管留置时间[(53.19±8.15)小时 vs. (73.25±15.51)小时,P 结论:ICG 技术在传统手术中的创新性应用,为患者提供了更多的选择:雾化吸入 ICG 的创新应用为小儿胸腔镜下肺内嵌塞的精确定位和病灶切除提供了可能。这最大限度地保留了正常肺实质,更好地改善了术后肺功能,缩短了术后恢复时间。
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来源期刊
Respiratory Research
Respiratory Research RESPIRATORY SYSTEM-
CiteScore
9.70
自引率
1.70%
发文量
314
审稿时长
4-8 weeks
期刊介绍: Respiratory Research publishes high-quality clinical and basic research, review and commentary articles on all aspects of respiratory medicine and related diseases. As the leading fully open access journal in the field, Respiratory Research provides an essential resource for pulmonologists, allergists, immunologists and other physicians, researchers, healthcare workers and medical students with worldwide dissemination of articles resulting in high visibility and generating international discussion. Topics of specific interest include asthma, chronic obstructive pulmonary disease, cystic fibrosis, genetics, infectious diseases, interstitial lung diseases, lung development, lung tumors, occupational and environmental factors, pulmonary circulation, pulmonary pharmacology and therapeutics, respiratory immunology, respiratory physiology, and sleep-related respiratory problems.
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