Oligometastatic Breast Cancer: Seeking the Cure by Redefining Stage IV Disease?

IF 3.8 2区医学 Q2 ONCOLOGY Current Treatment Options in Oncology Pub Date : 2024-11-14 DOI:10.1007/s11864-024-01275-4

Dionysia N Zouki, Eleni A Karatrasoglou, Georgios Pilichos, Elisavet Papadimitraki

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Abstract

Opinion statement: Breast cancer represents one of the most common malignancies worldwide. In early stages a combination of treatment strategies are offered with curative intent, whereas the therapeutic aim in metastatic disease is to provide the longest possible survival with an acceptable quality of life. The term "oligometastasis", first described by Hellmann and Weichselbaum in 1995, represents an intermediate state between local and systemic disease, where radical focal treatments to all metastatic lesions might have a curative potential. Due to sufficient lack of data, the proper management of oligometastatic disease remains even until today a highly unmet need. Surgery, radiotherapy or ablation (radiofrequency or cryotherapy) are among the local eradication therapies that could offer long-term outcomes in patients with oligometastatic breast cancer (OMBC). The present review aims to bring the readers up to the latest data regarding the management of OMBC according to the different organs involved by setting a framework of current treatment paradigms. It also brings to the forefront debatable questions requiring multidisciplinary approach and highlights the concerns arising from dealing with this clinically and biologically unique entity in everyday clinical practice.

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寡转移性乳腺癌：通过重新定义 IV 期疾病来寻求治愈？

意见陈述：乳腺癌是全球最常见的恶性肿瘤之一。在早期阶段，可采取综合治疗策略，以达到治愈目的，而转移性疾病的治疗目标则是尽可能延长患者的生存期，同时保证患者的生活质量。"少转移"（oligometastasis）一词由 Hellmann 和 Weichselbaum 于 1995 年首次描述，代表了一种介于局部和全身疾病之间的中间状态，在这种状态下，对所有转移病灶进行根治性病灶治疗可能具有治愈的潜力。由于缺乏足够的数据，对少转移灶疾病的适当治疗直到今天仍是一个极难满足的需求。手术、放疗或消融（射频或冷冻疗法）等局部根治疗法可为少转移性乳腺癌（OMBC）患者带来长期疗效。本综述旨在通过建立当前治疗范例的框架，为读者提供有关根据所涉及的不同器官治疗 OMBC 的最新数据。本综述还将需要多学科方法的争议性问题摆到了最前沿，并强调了在日常临床实践中处理这种临床和生物学上独特的实体时出现的问题。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Treatment Options in Oncology ONCOLOGY-

CiteScore

7.10

自引率

0.00%

发文量

113

审稿时长

>12 weeks

期刊介绍： This journal aims to review the most important, recently published treatment option advances in the field of oncology. By providing clear, insightful, balanced contributions by international experts, the journal intends to facilitate worldwide approaches to cancer treatment. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as endocrine tumors, lymphomas, neuro-oncology, and cancers of the breast, head and neck, lung, skin, gastrointestinal tract, and genitourinary region. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. We also provide commentaries from well-known oncologists, and an international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research.

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