Relationship between changes in nutritional status during treatment and overall survival of newly diagnosed nasopharyngeal carcinoma patients

IF 2.7 3区 医学 Q1 NURSING European Journal of Oncology Nursing Pub Date : 2024-10-31 DOI:10.1016/j.ejon.2024.102721
Wen-Pei Chang
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Abstract

Purpose

This study investigates the relationship between changes in nutritional status during treatment and overall survival in NPC patients.

Method

Using a prospective cohort design, the electronic health records of newly diagnosed NPC patients from a medical center in Taiwan (from January 1, 2018, to March 31, 2024) were analyzed. A total of 73 newly diagnosed NPC patients were tracked; nutritional indicators such as body mass index (BMI), prealbumin levels, and Patient-Generated Subjective Global Assessment (PG-SGA) scores were recorded at four time points: one week before treatment, the first week of treatment, and four and eight weeks after treatment began.

Results

The study found that most patients experienced a decrease in BMI (B = −0.62, p < .001) and prealbumin levels (B = −0.79, p = .015) during treatment, although BMI remained in the overweight range and prealbumin stayed within normal levels. PG-SGA scores increased (B = 1.01, p < .001), indicating a shift from low to moderate nutritional risk. Univariate Cox regression analysis showed that the Charlson Comorbidity Index (HR = 1.86, 95% CI: 1.38–2.51), NPC stage (HR = 15.67, 95% CI: 2.07–118.61), treatment method (HR = 2.96, 95% CI: 1.45–6.04), prealbumin (HR = 2.95, 95% CI: 1.46–5.99), and PG-SGA score trajectories (HR = 2.85, 95% CI: 1.27–6.40) were associated with overall survival. However, multivariate analysis revealed that the survival of NPC patients was only associated with CCI and NPC stage.

Conclusions

The study underscores the importance of monitoring nutritional status changes during treatment, particularly prealbumin and PG-SGA trajectories.
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新确诊鼻咽癌患者治疗期间营养状况变化与总生存期之间的关系。
目的:本研究探讨了鼻咽癌患者治疗期间营养状况变化与总生存期之间的关系:采用前瞻性队列设计,分析了台湾一家医疗中心新确诊的鼻咽癌患者的电子健康记录(2018 年 1 月 1 日至 2024 年 3 月 31 日)。共追踪了73名新确诊的鼻咽癌患者;在四个时间点记录了营养指标,如体重指数(BMI)、前白蛋白水平和患者自发主观全面评估(PG-SGA)评分:治疗前一周、治疗第一周、治疗开始后四周和八周:研究发现,大多数患者的体重指数都有所下降(B = -0.62,P 结论):该研究强调了在治疗过程中监测营养状况变化的重要性,尤其是白蛋白和 PG-SGA 的变化轨迹。
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来源期刊
CiteScore
4.40
自引率
3.60%
发文量
109
审稿时长
57 days
期刊介绍: The European Journal of Oncology Nursing is an international journal which publishes research of direct relevance to patient care, nurse education, management and policy development. EJON is proud to be the official journal of the European Oncology Nursing Society. The journal publishes the following types of papers: • Original research articles • Review articles
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