Association of overexpression of PLD6, CHRAC1 and PDCD5 with type 2 diabetes mellitus.

Q2 Medicine Medicinski Glasnik Pub Date : 2024-09-01 DOI:10.17392/1739-21-02

Ali Adel Dawood, Zayd Kays Omer, Alyaa Farouk Al-Omari

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Abstract

Aim: Diabetes type 2 (DT2) is a metabolic disease characterized by high blood sugar caused by insulin resistance and/or insufficient insulin production. The pathogenesis of DT2 is complicated by both genetic predisposition and environmental and lifestyle variables. At least 150 genetic variants have been linked to the probability of having DT2. The aim of this study was to determine the expression of PLD6, CHRAC1, and PDCD5 genes in type 2 diabetic patients.

Methods: Information on 12 DT2 patients was obtained from the Gene Expression Omnibus (GEO) using the series identification (ID) (GSE34008). The analysis tools GEO2R, String Utils (STRING), University of Alabama at Birmingham Cancer data analysis (UAL-CAN), and the Cancer Genome Atlas (TCGA) were used. The human protein atlas provided details on gene cancer.

Results: Only ten genes with expression differences ranging from low to high were selected. PLD6, CHRAC1, and PDCD5 were detected to have higher expression in patients compared to controls. The number of patients with primary pancreatic adenocarcinoma for SLC16A4, DERK2, and CHRAC1 was greater than that of healthy controls. Concerning the severity of cancer, all chosen genes demonstrated a greater proportion of affected individuals compared to the control group.

Conclusion: There are multiple genes whose increased expression is linked to type 2 diabetes.

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PLD6、CHRAC1 和 PDCD5 的过表达与 2 型糖尿病的关系。

目的：2 型糖尿病（DT2）是一种代谢性疾病，其特点是胰岛素抵抗和/或胰岛素分泌不足导致高血糖。遗传易感性以及环境和生活方式变量使 DT2 的发病机制变得复杂。至少有 150 个基因变异与 DT2 的患病概率有关。本研究旨在确定 PLD6、CHRAC1 和 PDCD5 基因在 2 型糖尿病患者中的表达情况：使用序列标识（ID）（GSE34008）从基因表达总库（GEO）中获取了 12 名 DT2 患者的信息。使用了 GEO2R、String Utils（STRING）、阿拉巴马大学伯明翰分校癌症数据分析（UAL-CAN）和癌症基因组图谱（TCGA）等分析工具。人类蛋白质图谱提供了癌症基因的详细信息：结果：只选取了 10 个表达差异从低到高不等的基因。与对照组相比，检测到 PLD6、CHRAC1 和 PDCD5 在患者中的表达较高。原发性胰腺腺癌患者中，SLC16A4、DERK2 和 CHRAC1 的表达量高于健康对照组。就癌症的严重程度而言，与对照组相比，所有被选中的基因都显示出更高的患病比例：结论：有多种基因的表达增加与 2 型糖尿病有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Medicinski Glasnik 医学-医学：内科

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Medicinski Glasnik (MG) is the official publication (two times per year) of the Medical Association of Zenica-Doboj Canton. Manuscripts that present of original basic and applied research from all fields of medicine (general and clinical practice, and basic medical sciences) are invited.