Phase separation of epigenetic landscape in cardiovascular diseases

IF 6.9 2区医学 Q1 MEDICINE, RESEARCH & EXPERIMENTAL Biomedicine & Pharmacotherapy Pub Date : 2024-11-09 DOI:10.1016/j.biopha.2024.117654

Sui Mao , Zhen-Yu Liu , Zhi-Yan Liu , Peng Liu , Li-Chan Lin , Ye Zhang , Jing-Jing Yang , Jian-Yuan Zhao , Hui Tao

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Abstract

The pathogenesis of cardiovascular diseases (CVDs) is intricate, with liquid-liquid phase separation (LLPS) considered a crucial regulatory mechanism. Epigenetics is closely intertwined with cardiovascular diseases, involving mechanisms such as DNA methylation, histone modifications, and non-coding RNAs (ncRNAs) that play pivotal roles in cardiovascular disease progression and regression. It is known that specific proteins and mRNAs associated with epigenetic modifications exhibit LLPS characteristics, influencing cardiovascular diseases. Consequently, targeting epigenetic modifications to modulate LLPS emerges as a promising strategy for cardiovascular diseases treatment. This review delves into the regulatory impact of liquid-liquid phase separation on cardiovascular diseases, with a specific focus on the epigenetic landscape. The current study sought to investigate the relationship between epigenetic landscape and phase separation in cardiovascular diseases development, as well as their therapeutic implications.

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心血管疾病中表观遗传景观的相位分离。

心血管疾病（CVDs）的发病机制错综复杂，其中液-液相分离（LLPS）被认为是一种关键的调控机制。表观遗传学与心血管疾病密切相关，涉及 DNA 甲基化、组蛋白修饰和非编码 RNA（ncRNA）等机制，这些机制在心血管疾病的进展和消退中发挥着关键作用。众所周知，与表观遗传修饰相关的特定蛋白质和 mRNA 具有 LLPS 特性，会对心血管疾病产生影响。因此，以表观遗传修饰为靶点调节 LLPS 成为治疗心血管疾病的一种有前景的策略。本综述深入探讨了液-液相分离对心血管疾病的调控影响，并特别关注了表观遗传学的情况。本研究试图探讨表观遗传学景观与相分离在心血管疾病发展中的关系及其治疗意义。

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来源期刊

Biomedicine & Pharmacotherapy 医学-药学

CiteScore

11.90

自引率

2.70%

发文量

1621

审稿时长

48 days

期刊介绍： Biomedicine & Pharmacotherapy stands as a multidisciplinary journal, presenting a spectrum of original research reports, reviews, and communications in the realms of clinical and basic medicine, as well as pharmacology. The journal spans various fields, including Cancer, Nutriceutics, Neurodegenerative, Cardiac, and Infectious Diseases.