A pilot study on the potential of photobiomodulation to safely modify symptoms of an overactive bladder.

Bladder (San Francisco, Calif.) Pub Date : 2024-09-11 eCollection Date: 2024-01-01 DOI:10.14440/bladder.2024.0014

Wendy F Bower, David Michael Whishaw, Erik Biros, Christine Baldrey, Mary P Galea

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Abstract

Background: Photobiomodulation (PBM) may stabilize autonomic neural drive from the pontine micturition Center to the urinary bladder in individuals with overactive bladder (OAB) symptoms.

Methods: A safety profile study preceded a single-case experimental design with repeated measures across subjects to establish the safety and effect direction of PBM to modify symptoms in patients with OAB.

Results: No adverse events occurred with PBM, specifically blood pressure remained unchanged. Urinary frequency improved significantly during the intervention and at follow-up. PBM therapy was associated with a meaningful impact on OAB-related quality of life and a small to medium-to-high effect size on OAB symptom severity.

Conclusion: Nasal application of PBM is safe and may impact OAB symptoms. A controlled trial of PBM in patients with lower urinary tract symptoms is warranted.

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一项关于光生物调节技术安全改善膀胱过度活动症症状潜力的试点研究。

背景：光生物调节（PBM）可稳定膀胱过度活动症（OAB）患者从桥脑排尿中枢到膀胱的自主神经驱动：一项安全性研究采用了单例实验设计，对不同受试者进行重复测量，以确定PBM治疗膀胱过度活动症患者症状的安全性和效果方向：结果：PBM未出现不良反应，特别是血压保持不变。在干预期间和随访期间，尿频明显改善。PBM疗法对与OAB相关的生活质量产生了有意义的影响，对OAB症状的严重程度产生了小到中到高的影响：结论：鼻腔应用 PBM 是安全的，可能会对 OAB 症状产生影响。有必要对下尿路症状患者进行 PBM 对照试验。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bladder (San Francisco, Calif.)

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