{"title":"Estriol in formation of mononuclear cells tolerogenic features","authors":"Irina Nekrasova, Sergei Shirshev","doi":"10.1016/j.jri.2024.104390","DOIUrl":null,"url":null,"abstract":"<div><div>Estriol (E<sub>3</sub>) is one of hormones whose synthesis is mainly associated with pregnancy. The hormone can also regulate immune cells functions. E<sub>3</sub> influence on monocyte indoleamine-2,3-dioxygenase (IDO1) activity and Treg and NK cells’ markers expression was investigated. LPS and IFN-γ stimulated IDO1 activity was augmented by Е<sub>3</sub> independently of the hormone doses. Both Е<sub>3</sub> concentrations increased CD4<sup>+</sup>Foxp3<sup>+</sup> lymphocytes percentage. This hormonal effect was mediated by protein kinase A. CD16 expression upon NK cells was reduced as a result of Е<sub>3</sub> influence. The data indicated that Е<sub>3</sub> is one of the factors which maintained immune tolerance during pregnancy and protected fetus preservation.</div></div>","PeriodicalId":16963,"journal":{"name":"Journal of Reproductive Immunology","volume":"166 ","pages":"Article 104390"},"PeriodicalIF":2.9000,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Reproductive Immunology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0165037824001992","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"IMMUNOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Estriol (E3) is one of hormones whose synthesis is mainly associated with pregnancy. The hormone can also regulate immune cells functions. E3 influence on monocyte indoleamine-2,3-dioxygenase (IDO1) activity and Treg and NK cells’ markers expression was investigated. LPS and IFN-γ stimulated IDO1 activity was augmented by Е3 independently of the hormone doses. Both Е3 concentrations increased CD4+Foxp3+ lymphocytes percentage. This hormonal effect was mediated by protein kinase A. CD16 expression upon NK cells was reduced as a result of Е3 influence. The data indicated that Е3 is one of the factors which maintained immune tolerance during pregnancy and protected fetus preservation.
期刊介绍：
Affiliated with the European Society of Reproductive Immunology and with the International Society for Immunology of Reproduction
The aim of the Journal of Reproductive Immunology is to provide the critical forum for the dissemination of results from high quality research in all aspects of experimental, animal and clinical reproductive immunobiology.
This encompasses normal and pathological processes of:
* Male and Female Reproductive Tracts
* Gametogenesis and Embryogenesis
* Implantation and Placental Development
* Gestation and Parturition
* Mammary Gland and Lactation.
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