{"title":"Refractory and Super-Refractory Status Epilepticus","authors":"Andrea O. Rossetti MD","doi":"10.1016/j.ncl.2024.07.002","DOIUrl":null,"url":null,"abstract":"","PeriodicalId":49759,"journal":{"name":"Neurologic Clinics","volume":null,"pages":null},"PeriodicalIF":2.4000,"publicationDate":"2024-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurologic Clinics","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0733861924000537","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
在癫痫状态（SE）患者中，潜在的生物背景是预后的主要变量。建议迅速实施治疗方案，包括使用足量的苯二氮卓类药物，然后静脉注射抗癫痫药物。如果出现难治性 SE，应在昏迷中对全身抽搐和非抽搐性 SE 使用全身麻醉剂，而对局灶性 SE 患者则应进一步尝试使用非镇静抗癫痫药物。应及早考虑对超级难治性 SE 患者使用生酮饮食和/或氯胺酮，对新发难治性 SE/发热诱发难治性癫痫综合征患者使用免疫疗法。心脏骤停后 SE 的药物治疗应以多模式预后结果为导向。
期刊介绍：
Targeted toward those in the fields of neurology, family medicine, otolaryngology, and pediatrics, Neurologic Clinics offers a broad view of current practice, as well as the evidence to support it. Published quarterly — in February, May, August, and November — each issue focuses on a single topic neurology, including hearing loss, cholesteatoma, rhinology, anosmia, dysphagia, and pediatric-specific ENT.
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