{"title":"POGK is a domesticated KRAB domain-containing transposable element with tumor suppressive functions in breast cancer.","authors":"Karen M Mann","doi":"10.1016/j.tcb.2024.11.002","DOIUrl":null,"url":null,"abstract":"<p><p>Transposable elements (TEs) account for 50% of the human genome and have essential functions as gene promoters. A subset of TEs is expressed in normal cells and differentially expressed in cancers, yet their biological significance is understudied. In a recent article, Tu et al. describe the tumor suppressive function of POGK, an expressed TE with a KRAB domain, and its cooperation with TRIM28 to repress ribosomal gene transcription in triple-negative breast cancer (TNBC).</p>","PeriodicalId":56085,"journal":{"name":"Trends in Cell Biology","volume":null,"pages":null},"PeriodicalIF":13.0000,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Trends in Cell Biology","FirstCategoryId":"99","ListUrlMain":"https://doi.org/10.1016/j.tcb.2024.11.002","RegionNum":1,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CELL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Transposable elements (TEs) account for 50% of the human genome and have essential functions as gene promoters. A subset of TEs is expressed in normal cells and differentially expressed in cancers, yet their biological significance is understudied. In a recent article, Tu et al. describe the tumor suppressive function of POGK, an expressed TE with a KRAB domain, and its cooperation with TRIM28 to repress ribosomal gene transcription in triple-negative breast cancer (TNBC).
期刊介绍：
Trends in Cell Biology stands as a prominent review journal in molecular and cell biology. Monthly review articles track the current breadth and depth of research in cell biology, reporting on emerging developments and integrating various methods, disciplines, and principles. Beyond Reviews, the journal features Opinion articles that follow trends, offer innovative ideas, and provide insights into the implications of new developments, suggesting future directions. All articles are commissioned from leading scientists and undergo rigorous peer-review to ensure balance and accuracy.
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