Dual Photoredox/Nickel Catalysis Enables Diastereoselective Synthesis of Multisubstituted γ-Lactams Using Alkyl-GeMe3 as Radical Precursors

IF 3.3 2区 化学 Q1 CHEMISTRY, ORGANIC The Journal of Organic Chemistry Pub Date : 2024-02-07 DOI:10.1021/acs.joc.3c0234810.1021/acs.joc.3c02348
Wen-Feng Li, Qing-Hao Xu, Qi-Yue Miao and Bin Xiao*, 
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Abstract

Herein, we report a single-step, multicomponent approach to versatile γ-lactams through dual photoredox/nickel-catalyzed dicarbofunctionalization of α,β-unsaturated γ-butyrolactam. This reaction utilized alkyl trimethylgermanium as a radical precursor and acyl chloride as the electrophile, demonstrating remarkable functional group compatibility.

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以烷基-GeMe3 为自由基前体,通过光氧化/镍双催化实现多取代γ-内酰胺的非对映选择性合成
在此,我们报告了一种通过α,β-不饱和γ-丁内酰胺的双光氧化/镍催化二卡伯基官能化来制备多功能γ-内酰胺的单步多组分方法。该反应利用烷基三甲基锗作为自由基前体,酰基氯作为亲电子体,表现出显著的官能团兼容性。
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来源期刊
The Journal of Organic Chemistry
The Journal of Organic Chemistry 化学-有机化学
CiteScore
6.20
自引率
11.10%
发文量
1467
审稿时长
2 months
期刊介绍: The Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.
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