Shaghayegh Mehdidoust, Saideh Rajai-Daryasarei, S. Sina Hosseini, Frank Rominger, Hamid Reza Bijanzadeh, Saeed Balalaie* and Sorour Ramezanpour,
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引用次数: 0
Abstract
A practical approach for rapid and efficient access to spirocyclic isobenzofurans is described. The reaction proceeds through the cycloaddition of 1,6-ynenone derivatives and 4-nitro-1,3-diarylbutan-1-ones, promoted by Cs2CO3 in the presence of l-proline as a catalyst. The advantages of this reaction include the formation of two C–C bonds and one C–O bond as well as mild reaction conditions. Extended spirocyclic isobenzofurans are obtained with good efficiency and diastereoselectivity under these mild conditions, and this new protocol avoids the use of any transition-metal reagents.
期刊介绍：
The Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.
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