Cs2CO3-Catalyzed Rauhut–Currier-Type Reaction for the Synthesis of 2,3-Dihydrobenzo[b]oxepin Derivatives

Abstract

The synthesis of fused benzoxepines relies on the use of complex substrates and methodologies. Herein, we report our experimental and theoretical findings about an unprecedented Rauhut–Currier-type reaction catalyzed by Cs₂CO₃ to access these important compounds. The developed methodology avoids the use of phosphine- or amine-based catalysts and additives. The reaction can be performed under microwave irradiation and proceeds with complete chemoselectivity.