Spatiotemporal Concurrent PARP Inhibitor Sensitization Based on Radiation-Responsive Nanovesicles for Lung Cancer Chemoradiotherapy (Adv. Healthcare Mater. 28/2024)
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引用次数: 0
Abstract
Nanovesicles
In article 2400908, Fei Kang, Jing Wang, Xiaoyuan Chen, and co-workers develop CV-Au NVs, defined as concurrent PARP inhibitor sensitization based on radiation-responsive nanovesicles. Upon irradiation, the nanovesicles are disintegrated, spatiotemporally releasing the loaded veliparib (PARP inhibitor) and cisplatin. The combined action of veliparib and cisplatin can increase radiation-induced DNA damage and promote apoptosis of tumor cells, enhancing the chemoradiotherapy efficacy of lung cancer.
期刊介绍：
Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.
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