{"title":"Biomimetic Nano-Regulator that Induces Cuproptosis and Lactate-Depletion Mediated ROS Storm for Metalloimmunotherapy of Clear Cell Renal Cell Carcinoma (Adv. Healthcare Mater. 28/2024)","authors":"Xiaotong Xu, Huimin Li, Binghua Tong, Weijie Zhang, Xiaofei Wang, Yue Wang, Geng Tian, Zhaowei Xu, Guilong Zhang","doi":"10.1002/adhm.202470182","DOIUrl":null,"url":null,"abstract":"<p><b>Nanoimmunotherapy</b></p><p>Specific metabolism reprogramming triggered lactate accumulation in ccRCC serves as a “moat” to protect cancer cells from immune- and chemotherapies. In article 2400204, Geng Tian, Zhaowei Xu, Guilong Zhang, and co-workers develop a novel “parachute specops”, which are disguised with cancer cell membrane and carry special weapons (LOx and copper), to achieve precise strike for ccRCC through inducing ROS storm, cuproptosis and enhanced immunotherapy.\n\n <figure>\n <div><picture>\n <source></source></picture><p></p>\n </div>\n </figure></p>","PeriodicalId":113,"journal":{"name":"Advanced Healthcare Materials","volume":"13 28","pages":""},"PeriodicalIF":10.0000,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/adhm.202470182","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Advanced Healthcare Materials","FirstCategoryId":"5","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/adhm.202470182","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"ENGINEERING, BIOMEDICAL","Score":null,"Total":0}
引用次数: 0
Abstract
Nanoimmunotherapy
Specific metabolism reprogramming triggered lactate accumulation in ccRCC serves as a “moat” to protect cancer cells from immune- and chemotherapies. In article 2400204, Geng Tian, Zhaowei Xu, Guilong Zhang, and co-workers develop a novel “parachute specops”, which are disguised with cancer cell membrane and carry special weapons (LOx and copper), to achieve precise strike for ccRCC through inducing ROS storm, cuproptosis and enhanced immunotherapy.
期刊介绍：
Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.
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