Lewis Acid Promotes Three-Component Cyclization to Construct Dithioxazole Derivatives

IF 3.3 2区 化学 Q1 CHEMISTRY, ORGANIC The Journal of Organic Chemistry Pub Date : 2024-11-16 DOI:10.1021/acs.joc.4c01723
Kai Zou, Anquan Li, Yitong Chen, Gao Cao, Baofu Zhu
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Abstract

A simple and effective strategy for the construction of disulfide-substituted oxazole derivatives from amides, ynals, and acetyl disulfides via a Lewis acid-promoted three-component reaction has been reported. In addition, this reaction possesses other unique advantages, such as transition-metal-free catalysis, the production of disulfides, good functional group tolerance, and good regioselectivity.

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路易斯酸促进三组分环化以构建二硫恶唑衍生物
据报道,一种简单有效的策略可通过路易斯酸促进的三组分反应,从酰胺、炔烃和乙酰基二硫化物构建二硫代噁唑衍生物。此外,该反应还具有其他独特优势,如无过渡金属催化、可生成二硫化物、良好的官能团耐受性和良好的区域选择性。
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来源期刊
The Journal of Organic Chemistry
The Journal of Organic Chemistry 化学-有机化学
CiteScore
6.20
自引率
11.10%
发文量
1467
审稿时长
2 months
期刊介绍: The Journal of Organic Chemistry welcomes original contributions of fundamental research in all branches of the theory and practice of organic chemistry. In selecting manuscripts for publication, the editors place emphasis on the quality and novelty of the work, as well as the breadth of interest to the organic chemistry community.
期刊最新文献
Lewis Acid Promotes Three-Component Cyclization to Construct Dithioxazole Derivatives Chemoselective Dehydrogenation and Hetero-Arylation of Amides via Radical Translocation Enabled by Photoexcited Triplet Ketone Catalysis Robust Organocatalytic Three-Component Approach to 1,3-Diarylallylidene Pyrazolones via Consecutive Double Condensation Reactions Issue Publication Information Issue Editorial Masthead
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