[Long-term efficacy and safety with sacituzumab govitecan in a patient with triple-negative breast cancer, multi-treated and high body mass index.]

Q3 Medicine Recenti progressi in medicina Pub Date : 2024-11-01 DOI:10.1701/4365.43617
Maria Morritti
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Abstract

The metastatic triple negative breast cancer (mTNBC) represents a particularly aggressive form of breast cancer that frequently affects young women under the age of 50. Obesity at the time of breast cancer diagnosis is associated with a worse prognosis. Compared to the recent past, increasing life expectancy and quality of life for patients with mTNBC is now a possible challenge, thanks to a new drug, sacituzumab govitecan (SG), an anti-Trop-2 antibody drug conjugate approved as monotherapy for the treatment of these patients. The presented clinical case documents the efficacy and safety of long-term treatment with SG in an obese young woman with mTNBC who has already undergone multiple treatments. The patient is still responding after 20 months of treatment with good quality of life and social interactions.

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[萨希妥珠单抗戈维替康对一名三阴性乳腺癌患者的长期疗效和安全性,该患者接受过多种治疗且体重指数较高。]
转移性三阴性乳腺癌(mTNBC)是一种侵袭性特别强的乳腺癌,经常侵袭 50 岁以下的年轻女性。乳腺癌确诊时的肥胖与预后较差有关。与过去相比,现在有了一种新药--sacituzumab govitecan(SG),它是一种抗肿瘤坏死因子-2(Trop-2)的抗体药物共轭物,已被批准作为治疗这类患者的单一疗法。本临床病例记录了一位已接受过多种治疗的年轻肥胖 mTNBC 女性患者接受 SG 长期治疗的有效性和安全性。经过 20 个月的治疗后,患者的反应仍然良好,生活质量和社会交往状况良好。
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来源期刊
Recenti progressi in medicina
Recenti progressi in medicina Medicine-Medicine (all)
CiteScore
0.90
自引率
0.00%
发文量
143
期刊介绍: Giunta ormai al sessantesimo anno, Recenti Progressi in Medicina continua a costituire un sicuro punto di riferimento ed uno strumento di lavoro fondamentale per l"ampliamento dell"orizzonte culturale del medico italiano. Recenti Progressi in Medicina è una rivista di medicina interna. Ciò significa il recupero di un"ottica globale e integrata, idonea ad evitare sia i particolarismi della informazione specialistica sia la frammentazione di quella generalista.
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