PinX1 plays multifaceted roles in human cancers: a review and perspectives.

IF 2.6 4区生物学 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY Molecular Biology Reports Pub Date : 2024-11-17 DOI:10.1007/s11033-024-10082-x

Dian You, Kaiwen Tong, Yuan Li, Ting Zhang, Yongqiang Wu, Ling Wang, Guangming Chen, Xiaoying Zhang

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Abstract

Background: Pin2/TRF1 interacting protein X1 (PinX1), a telomerase inhibitor, is located at human chromosome 8p23. This region is important for telomere length maintenance and chromosome stability, both of which are essential for regulating human ageing and associated diseases.

Methods and results: We investigated the research progress of PinX1 in human cancers. In cancers, the expression levels of PinX1 mRNA and protein vary according to cancer cell types, and PinX1 plays a critical role in the regulation of cancer development and progression. Additionally, a review of the literature indicates that PinX1 is involved in mitosis and affects the sensitivity of cancer cells to radiation-induced DNA damage. Therefore, PinX1 has therapeutic potential for cancer, and understanding the function of PinX1 in the regulation of cancers is crucial for improving treatment. In this review, we discuss the expression level of PinX1 in a variety of cancers and how it affects the implicated pathways. Additionally, we outline the function of PinX1 in cancer cells and provide a theoretical basis for PinX1-related cancer therapy.

Conclusions: PinX1 has promising prospects in future cancer therapeutics. This review may provide theoretical support for researchers in this field.

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PinX1 在人类癌症中发挥着多方面的作用：综述与展望。

背景：端粒酶抑制因子Pin2/TRF1相互作用蛋白X1（PinX1）位于人类染色体8p23。该区域对端粒长度的维持和染色体的稳定性非常重要，而端粒长度的维持和染色体的稳定性对于调控人类衰老和相关疾病至关重要：我们调查了 PinX1 在人类癌症中的研究进展。在癌症中，PinX1 mRNA 和蛋白质的表达水平因癌细胞类型而异，PinX1 在调控癌症的发生和发展中起着关键作用。此外，文献综述表明，PinX1 参与有丝分裂，并影响癌细胞对辐射诱导的 DNA 损伤的敏感性。因此，PinX1 具有治疗癌症的潜力，而了解 PinX1 在癌症调控中的功能对于改善治疗至关重要。在这篇综述中，我们讨论了 PinX1 在多种癌症中的表达水平，以及它如何影响相关通路。此外，我们还概述了 PinX1 在癌细胞中的功能，并为 PinX1 相关的癌症治疗提供了理论依据：结论：PinX1 在未来的癌症治疗中具有广阔的前景。本综述可为该领域的研究人员提供理论支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Biology Reports 生物-生化与分子生物学

CiteScore

5.00

自引率

0.00%

发文量

1048

审稿时长

5.6 months

期刊介绍： Molecular Biology Reports publishes original research papers and review articles that demonstrate novel molecular and cellular findings in both eukaryotes (animals, plants, algae, funghi) and prokaryotes (bacteria and archaea).The journal publishes results of both fundamental and translational research as well as new techniques that advance experimental progress in the field and presents original research papers, short communications and (mini-) reviews.