Prior self-control exertion decreases pre-frontal cortex oxygenation during a CO2 rebreathing challenge but does not affect perceptions of dyspnoea or tolerance time

IF 1.9 4区 医学 Q3 PHYSIOLOGY Respiratory Physiology & Neurobiology Pub Date : 2024-11-14 DOI:10.1016/j.resp.2024.104371
J.C. Brown, R. Boat, N.C. Williams, M.A. Johnson, G.R. Sharpe
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Abstract

Introduction

Dyspnoea perception is influenced by a complex interplay of physiological, psychological, and environmental factors. Recently, we showed that males with high trait self-control experience less dyspnoea and persist for longer in a carbon dioxide (CO2) rebreathing challenge than males with low trait self-control. As self-control can also vary within individuals (state self-control), the primary aim of the present study was to investigate whether prior self-control exertion influenced perceptions of dyspnoea and tolerance of a CO2 rebreathing challenge in healthy young males. We also used functional near-infrared spectroscopy (fNIRS) to assess haemodynamic activity of the pre-frontal cortex (PFC) which is a region of interest (ROI) in dyspnoea research, and the primary brain region associated with exertion of self-control.

Methods

In a within-subjects design, fifteen healthy young males completed an easy (congruent) Stroop task (control condition) and a difficult (incongruent) Stroop task (prior self-control exertion, experimental condition) followed by a CO2 rebreathing challenge until the limit of tolerance. Changes in oxyhaemoglobin (ΔO2Hb) and deoxyhaemoglobin (ΔHHb) were assessed continuously in the Stroop task and CO2 rebreathing challenge. During the CO2 rebreathing challenge, dyspnoea intensity and unpleasantness were rated every 30 s.

Results

Prior self-control exertion did not affect perceptions of dyspnoea or tolerance time in the CO2 rebreathing challenge (all P > 0.05). ΔO2Hb from baseline was higher in the left (+38 %) and right (+44 %) pre-frontal cortices during the difficult Stroop task than the easy Stroop task (both P < 0.05). During the subsequent CO2 rebreathing challenge, ΔO2Hb was attenuated following prior self-control exertion in the left PFC.

Conclusions

Although prior self-control exertion decreased pre-frontal cortex oxygenation during a subsequent CO2 rebreathing challenge, there was no change in tolerance time or perceptions of dyspnoea.
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在二氧化碳呼吸挑战中,事先的自我控制用力会降低前额叶皮层的含氧量,但不会影响对呼吸困难或耐受时间的感知。
简介呼吸困难的感知受到生理、心理和环境因素复杂的相互作用的影响。最近,我们的研究表明,与特质自我控制能力低的男性相比,特质自我控制能力高的男性在二氧化碳(CO2)再呼吸挑战中呼吸困难的程度较轻,持续时间较长。由于自我控制能力在个体内部也可能存在差异(状态自我控制能力),本研究的主要目的是调查先前的自我控制能力是否会影响健康年轻男性对呼吸困难的感知以及对二氧化碳再呼吸挑战的耐受性。我们还使用功能性近红外光谱(fNIRS)来评估前额叶皮层(PFC)的血流动力学活动,前额叶皮层是呼吸困难研究的兴趣区(ROI),也是与自我控制能力相关的主要脑区:在受试者内设计中,15 名健康的年轻男性分别完成了一项简单(一致)的 Stroop 任务(对照条件)和一项困难(不一致)的 Stroop 任务(事先施加自我控制,实验条件),然后进行二氧化碳再呼吸挑战,直至达到耐受极限。在斯特罗普任务和二氧化碳再呼吸挑战中,连续评估氧合血红蛋白(ΔO2Hb)和脱氧血红蛋白(ΔHHb)的变化。在二氧化碳再呼吸挑战过程中,每隔 30 秒对呼吸困难的强度和难受程度进行评分:结果:在二氧化碳再呼吸挑战中,之前的自我控制用力并不影响呼吸困难的感觉或耐受时间(所有 P > 0.05)。在执行困难的 Stroop 任务时,左侧(+38%)和右侧(+44%)前额叶皮层的 ΔO2Hb 与基线相比均高于执行简单的 Stroop 任务时的 ΔO2Hb (均为 P <0.05)。在随后的二氧化碳再呼吸挑战中,ΔO2Hb在左侧前额叶皮质之前的自我控制消耗后减弱:结论:虽然在随后的二氧化碳再呼吸挑战中,之前的自我控制消耗降低了前额叶皮层的氧合,但耐受时间或呼吸困难的感觉没有变化。
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来源期刊
CiteScore
4.80
自引率
8.70%
发文量
104
审稿时长
54 days
期刊介绍: Respiratory Physiology & Neurobiology (RESPNB) publishes original articles and invited reviews concerning physiology and pathophysiology of respiration in its broadest sense. Although a special focus is on topics in neurobiology, high quality papers in respiratory molecular and cellular biology are also welcome, as are high-quality papers in traditional areas, such as: -Mechanics of breathing- Gas exchange and acid-base balance- Respiration at rest and exercise- Respiration in unusual conditions, like high or low pressure or changes of temperature, low ambient oxygen- Embryonic and adult respiration- Comparative respiratory physiology. Papers on clinical aspects, original methods, as well as theoretical papers are also considered as long as they foster the understanding of respiratory physiology and pathophysiology.
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