本文全面综述了B细胞导向疗法对严重急性呼吸系统综合征冠状病毒2疫苗免疫的影响,重点探讨了该疗法对自身免疫性炎症性风湿病(AIIRD)的影响。利妥昔单抗(RTX)是已在自身免疫性炎症性风湿病(AIIRD)中研究过的主要B细胞消耗药物,也是本综述的重点。我们回顾了 B 细胞在疫苗反应中的关键作用,并提出了管理和预测 B 细胞耗竭患者疫苗反应的策略。我们强调,在预测疫苗反应和制定指南以确保 RTX 治疗患者获得最佳疗效时,需要将患者分成不同的群体。
期刊介绍:
Rheumatic Disease Clinics updates you on the latest trends in patient management, keeps you up to date on the newest advances, and provides a sound basis for choosing treatment options. Each issue (February, May, August, and November) focuses on a single topic in rheumatology and is presented under the direction of an experienced editor. Topics include osteoarthritis, rheumatoid arthritis, crystal diseases, MSK exam, disorders of the bone, immunodeficiency states, lupus, neuromuscular disease, pain disorders, scleroderma, vasculitis, pediatrics, therapeutics, treatment guidelines, and treatment modalities.