Effect of preventive chemotherapy for neglected tropical diseases in Indonesia from 1992 to 2022: A systematic review and meta-analysis.

IF 2.6 4区医学 Q2 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH Tropical Medicine & International Health Pub Date : 2024-12-01 Epub Date: 2024-11-16 DOI:10.1111/tmi.14057

Elsa Herdiana Murhandarwati, Ari Probandari, Rizqiani Amalia Kusumasari, Astri Ferdiana, Christina Yeni Kustanti, Kharisma Dewi, Siti Nadia Tarmizi, Luh Putu Lila Wulandari, Gill Schierhout, Lucia Romani, John Kaldor, Susana Vaz Nery

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Abstract

Objectives: This study aimed to describe the prevalence of lymphatic filariasis (LF), soil-transmitted helminthiasis (STH) and schistosomiasis (SC) in Indonesia before and after PC implementation through a systematic review and meta-analysis.

Methods: Embase, MEDLINE, PubMed, Scopus, Web of Science and Google Scholar were searched for articles published between 1 January 1992 and 31 December 2022, reporting LF, STH and SC in Indonesia. Using the Ministry of Health lists of districts receiving PC programs, we identified whether data collection was conducted before or after PC implementation in that particular district. A meta-analysis was performed with a random-effects model applied to pool pre- and post-PC prevalence of LF, STH and SC.

Results: Overall, 195 studies were included. The pooled prevalence of LF was 9.72% (95% CI, 5.56%-13.87%). The pre-PC pooled prevalence of LF was 11.48% (95% CI, 5.52%-17.45%). The prevalence decreased after PC implementation, and the pooled prevalence was 7.12% (95% CI, 1.79%-12.44%). The overall prevalence of STH was 35.16% (95% CI, 30.36%-39.96%). The pre-PC prevalence of STH was 36.29% (95% CI, 30.37%-42.20%). The post-PC prevalence of STH decreased at 31.93% (95% CI, 24.25%-39.62%), although the difference between before and after PC was not significant (p = 0.379). Only nine studies investigated the prevalence of SC; based on the random-effects model, the pooled prevalence was 21.90% (95% CI, 4.88%-38.92%). Owing to the scarcity of studies, we could not perform the funnel tests for publication bias and moderating variables of the pooled prevalence for SC.

Conclusions: The prevalence of LF and STH decreased after PC implementation, although it was not significant. The difference for SC could not be assessed because of limited post-PC data. The uneven distribution of research and the lack of standardised sampling methods may not fully capture the situation.

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1992年至2022年印度尼西亚被忽视热带病预防性化疗的效果：系统回顾和荟萃分析。

研究目的本研究旨在通过系统综述和荟萃分析，描述印度尼西亚在 PC 实施前后淋巴丝虫病（LF）、土壤传播蠕虫病（STH）和血吸虫病（SC）的流行情况：在 Embase、MEDLINE、PubMed、Scopus、Web of Science 和 Google Scholar 中检索了 1992 年 1 月 1 日至 2022 年 12 月 31 日期间发表的、报道印度尼西亚 LF、STH 和 SC 的文章。通过卫生部提供的接受 PC 计划的地区名单，我们确定了数据收集工作是在特定地区实施 PC 计划之前还是之后进行的。我们采用随机效应模型进行了荟萃分析，以汇总 PC 实施前和实施后的 LF、STH 和 SC 感染率：结果：共纳入 195 项研究。LF 的汇总流行率为 9.72%（95% CI，5.56%-13.87%）。PC 实施前，LF 的总体流行率为 11.48%（95% CI，5.52%-17.45%）。PC 实施后，患病率有所下降，汇总患病率为 7.12%（95% CI，1.79%-12.44%）。STH 的总体流行率为 35.16%（95% CI，30.36%-39.96%）。PC 前的 STH 感染率为 36.29%（95% CI，30.37%-42.20%）。PC 后的 STH 感染率下降至 31.93%（95% CI，24.25%-39.62%），但 PC 前后的差异并不显著（P = 0.379）。只有 9 项研究调查了 SC 的患病率；根据随机效应模型，汇总患病率为 21.90%（95% CI，4.88%-38.92%）。由于研究较少，我们无法对SC的汇总流行率进行发表偏倚和调节变量的漏斗检验：结论：实施 PC 后，LF 和 STH 的流行率有所下降，但下降幅度不大。由于 PC 实施后的数据有限，因此无法评估 SC 的差异。研究分布不均以及缺乏标准化的抽样方法可能无法完全反映实际情况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Tropical Medicine & International Health 医学-公共卫生、环境卫生与职业卫生

CiteScore

4.80

自引率

0.00%

发文量

129

审稿时长

6 months

期刊介绍： Tropical Medicine & International Health is published on behalf of the London School of Hygiene and Tropical Medicine, Swiss Tropical and Public Health Institute, Foundation Tropical Medicine and International Health, Belgian Institute of Tropical Medicine and Bernhard-Nocht-Institute for Tropical Medicine. Tropical Medicine & International Health is the official journal of the Federation of European Societies for Tropical Medicine and International Health (FESTMIH).