Spontaneous cerebrovascular reactivity at rest in older adults with and without mild cognitive impairment and memory deficits.

IF 13 1区医学 Q1 CLINICAL NEUROLOGY Alzheimer's & Dementia Pub Date : 2024-11-18 DOI:10.1002/alz.14396

Allison C Engstrom, John Paul M Alitin, Arunima Kapoor, Shubir Dutt, Trevor Lohman, Isabel J Sible, Anisa J Marshall, Fatemah Shenasa, Aimée Gaubert, Farrah Ferrer, Amy Nguyen, David Robert Bradford, Kathleen Rodgers, Lorena Sordo, Elizabeth Head, Xingfeng Shao, Danny J J Wang, Daniel A Nation

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Abstract

Introduction: Older adults with mild cognitive impairment (MCI) exhibit deficits in cerebrovascular reactivity (CVR), suggesting CVR is a biomarker for vascular contributions to MCI. This study examined if spontaneous CVR is associated with MCI and memory impairment.

Methods: One hundred sixty-one older adults free of dementia or major neurological/psychiatric disorders were recruited. Participants underwent clinical interviews, cognitive testing, venipuncture for Alzheimer's disease (AD) biomarkers, and brain magnetic resonance imaging. Spontaneous CVR was quantified during 5 minutes of rest. Respiratory gases analyzed through nasal cannula to quantify end-tidal carbon dioxide (_ETCO₂) levels were used to estimate CVR.

Results: Whole brain CVR was negatively associated with age, but not MCI. Lower CVR in the parahippocampal gyrus (PHG) was found in participants with MCI and was linked to worse memory performance on memory tests. Results remained significant after adjusting for AD biomarkers and vascular risk factors.

Discussion: Spontaneous CVR deficits in the PHG are observed in older adults with MCI and memory impairment, suggesting medial temporal microvascular dysfunction is observed in cognitive decline.

Highlights: Aging is associated with decline in whole brain spontaneous cerebrovascular reactivity (CVR). Older adults with mild cognitive impairment exhibit deficits in spontaneous CVR in the parahippocampal gyrus (PHG). Memory impairment is correlated with reduced spontaneous CVR in the PHG.

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患有和未患有轻度认知障碍和记忆缺陷的老年人在静息状态下的自发性脑血管反应性。

简介患有轻度认知障碍（MCI）的老年人表现出脑血管反应性（CVR）缺陷，这表明CVR是导致MCI的血管因素的生物标志物。本研究探讨了自发性 CVR 是否与 MCI 和记忆损伤有关：招募了 161 名无痴呆症或主要神经/精神疾病的老年人。参与者接受了临床访谈、认知测试、阿尔茨海默病（AD）生物标志物静脉穿刺检查和脑磁共振成像检查。对休息 5 分钟时的自发 CVR 进行了量化。通过鼻插管分析呼吸气体，量化潮气末二氧化碳（ETCO2）水平，用于估算CVR：结果：全脑 CVR 与年龄呈负相关，但与 MCI 无关。MCI患者大脑海马旁回（PHG）的CVR较低，这与记忆测试中记忆力较差有关。在对AD生物标志物和血管风险因素进行调整后，结果仍有意义：讨论：在患有 MCI 和记忆障碍的老年人中观察到 PHG 中存在自发性 CVR 缺陷，这表明在认知能力下降过程中会出现颞叶内侧微血管功能障碍：衰老与全脑自发脑血管反应性（CVR）下降有关。患有轻度认知障碍的老年人表现出大脑海马旁回（PHG）自发脑血管反应性的缺陷。记忆损伤与 PHG 的自发 CVR 降低有关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.