The impact of rhG-CSF on risk of recurrence after postoperative chemotherapy in NSCLC Patients: A retrospective cohort study.

IF 4.8 2区医学 Q2 IMMUNOLOGY International immunopharmacology Pub Date : 2024-11-16 DOI:10.1016/j.intimp.2024.113519

Tong Wang, Weiwei Hong, Xinyuan Yao, Chen Fang, Xiaoying Qian, Biao Yu, Bingbiao Zhou, Xin Ye, Yong Wang, Yong Li

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Abstract

Purpose: Recombinant human granulocyte colony-stimulating factor (rhG-CSF) is widespread in the prevention and treatment of blood-related toxic effects associated with chemotherapy. This study aimed to explore the correlation between rhG-CSF and the recurrence of non-small cell lung cancer (NSCLC) in patients who have undergone postoperative chemotherapy.

Methods: Our study encompassed 517 NSCLC patients at pathological stage I-III, who underwent surgical removal and subsequent chemotherapy from January 2012 to December 2019 at the First Affiliated Hospital of Nanchang University. The research focused on evaluating the separate impact of rhG-CSF on the likelihood of postoperative recurrence. The analysis employed both univariate and multivariate Cox regression models.

Results: Of 517 NSCLC patients, 123 patients did not receive rhG-CSF, while 394 patients received rhG-CSF. Unexpectedly, it was discovered that rhG-CSF usage correlated with the emergence of distant metastasis (HR: 1.8, 95 %CI 1.2-2.7, p = 0.005), though not with local recurrence (HR: 1.4, 95 %CI 0.9-2.3, p = 0.142). By multifactorial Cox analysis, rhG-CSF was an independent risk factor for distant metastasis (adjusted HR: 1.7, 95 %CI 1.0-2.6, p = 0.033). We additionally discovered that rhG-CSF could increase the risk of brain metastasis (adjusted HR: 3.9, 95 %CI 1.5-9.8, p = 0.005) and bone metastasis (adjusted HR: 3.1, 95 %CI 1.2-8.2, p = 0.02).

Conclusion: Our findings indicate that rhG-CSF independently contributes to the risk of distant metastasis, yet it shows no correlation with local recurrence. Furthermore, employing rhG-CSF played a crucial role in predicting brain metastasis and bone metastasis after postoperative chemotherapy in NSCLC patients.

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rhG-CSF 对 NSCLC 患者术后化疗后复发风险的影响：回顾性队列研究

目的：重组人粒细胞集落刺激因子（rhG-CSF重组人粒细胞集落刺激因子（rhG-CSF）广泛用于预防和治疗化疗引起的血液相关毒性反应。本研究旨在探讨rhG-CSF与术后化疗患者非小细胞肺癌（NSCLC）复发的相关性：我们的研究涵盖了2012年1月至2019年12月在南昌大学第一附属医院接受手术切除和后续化疗的病理分期为I-III期的517例NSCLC患者。研究重点是评估 rhG-CSF 对术后复发可能性的单独影响。分析采用了单变量和多变量Cox回归模型：在517名NSCLC患者中，123名患者未接受rhG-CSF治疗，394名患者接受了rhG-CSF治疗。意外的是，研究发现rhG-CSF的使用与远处转移的出现相关（HR：1.8，95 %CI 1.2-2.7，p = 0.005），但与局部复发无关（HR：1.4，95 %CI 0.9-2.3，p = 0.142）。通过多因素 Cox 分析，rhG-CSF 是远处转移的独立危险因素（调整后 HR：1.7，95 %CI 1.0-2.6，p = 0.033）。我们还发现，rhG-CSF可增加脑转移（调整后HR：3.9，95 %CI 1.5-9.8，p = 0.005）和骨转移（调整后HR：3.1，95 %CI 1.2-8.2，p = 0.02）的风险：我们的研究结果表明，rhG-CSF 可独立增加远处转移的风险，但与局部复发无相关性。此外，采用rhG-CSF在预测NSCLC患者术后化疗后脑转移和骨转移方面起着至关重要的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International immunopharmacology 医学-免疫学

CiteScore

8.40

自引率

3.60%

发文量

935

审稿时长

53 days

期刊介绍： International Immunopharmacology is the primary vehicle for the publication of original research papers pertinent to the overlapping areas of immunology, pharmacology, cytokine biology, immunotherapy, immunopathology and immunotoxicology. Review articles that encompass these subjects are also welcome. The subject material appropriate for submission includes: • Clinical studies employing immunotherapy of any type including the use of: bacterial and chemical agents; thymic hormones, interferon, lymphokines, etc., in transplantation and diseases such as cancer, immunodeficiency, chronic infection and allergic, inflammatory or autoimmune disorders. • Studies on the mechanisms of action of these agents for specific parameters of immune competence as well as the overall clinical state. • Pre-clinical animal studies and in vitro studies on mechanisms of action with immunopotentiators, immunomodulators, immunoadjuvants and other pharmacological agents active on cells participating in immune or allergic responses. • Pharmacological compounds, microbial products and toxicological agents that affect the lymphoid system, and their mechanisms of action. • Agents that activate genes or modify transcription and translation within the immune response. • Substances activated, generated, or released through immunologic or related pathways that are pharmacologically active. • Production, function and regulation of cytokines and their receptors. • Classical pharmacological studies on the effects of chemokines and bioactive factors released during immunological reactions.